John A. DeSimone, Ph.D.

Affiliations: 
Physiology and Biophysics Virginia Commonwealth University, Richmond, VA, United States 
Area:
Taste system, sensory transduction, sodium taste
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"John DeSimone"
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Children

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Robert E. Stewart post-doc 1994-1996 VCU

Collaborators

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Gerard Heck collaborator 1978-2009 VCU
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Publications

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Qian J, Mummalaneni S, Phan TT, et al. (2017) Cyclic-AMP regulates postnatal development of neural and behavioral responses to NaCl in rats. Plos One. 12: e0171335
DeSimone JA. (2017) The dependence of the phasic response of the taste nerves on stimulus flow rate arises in the diffusion boundary layer region at the lingual surface: A convective-diffusion analysis Chemical Engineering Science. 168: 289-308
Ren ZJ, Mummalaneni S, Qian J, et al. (2015) Nicotinic Acetylcholine Receptor (nAChR) Dependent Chorda Tympani Taste Nerve Responses to Nicotine, Ethanol and Acetylcholine. Plos One. 10: e0127936
DeSimone JA, Phan TH, Mummalaneni S, et al. (2015) Regulatory Effects of Ca2+ and H+ on the Rat Chorda Tympani Response to NaCl and KCl. Chemical Senses. 40: 401-12
Kendig DM, Hurst NR, Bradley ZL, et al. (2014) Activation of the umami taste receptor (T1R1/T1R3) initiates the peristaltic reflex and pellet propulsion in the distal colon. American Journal of Physiology. Gastrointestinal and Liver Physiology. 307: G1100-7
Mummalaneni S, Qian J, Phan TH, et al. (2014) Effect of ENaC modulators on rat neural responses to NaCl. Plos One. 9: e98049
Ren Z, Rhyu MR, Phan TH, et al. (2013) TRPM5-dependent amiloride- and benzamil-insensitive NaCl chorda tympani taste nerve response. American Journal of Physiology. Gastrointestinal and Liver Physiology. 305: G106-17
Dewis ML, Phan TH, Ren Z, et al. (2013) N-geranyl cyclopropyl-carboximide modulates salty and umami taste in humans and animal models. Journal of Neurophysiology. 109: 1078-90
Desimone JA, Ren Z, Phan TH, et al. (2012) Changes in taste receptor cell [Ca2+]i modulate chorda tympani responses to salty and sour taste stimuli. Journal of Neurophysiology. 108: 3206-20
Coleman J, Williams A, Phan TH, et al. (2011) Strain differences in the neural, behavioral, and molecular correlates of sweet and salty taste in naive, ethanol- and sucrose-exposed P and NP rats. Journal of Neurophysiology. 106: 2606-21
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