Tarek Z. Deeb, Ph.D.

Affiliations: 
2007 The George Washington University, Washington, DC, United States 
Area:
Neuroscience Biology, Physiology Biology
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"Tarek Deeb"
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Tim G. Hales grad student 2007 The George Washington University
 (The influence of the cytoplasmic MA -stretch on ion conduction in cationic cysteine -loop receptors.)
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Publications

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Kahle KT, Deeb TZ, Puskarjov M, et al. (2013) Modulation of neuronal activity by phosphorylation of the K-Cl cotransporter KCC2. Trends in Neurosciences. 36: 726-37
Baptista-Hon DT, Deeb TZ, Lambert JJ, et al. (2013) The minimum M3-M4 loop length of neurotransmitter-activated pentameric receptors is critical for the structural integrity of cytoplasmic portals. The Journal of Biological Chemistry. 288: 21558-68
Deeb TZ, Nakamura Y, Frost GD, et al. (2013) Disrupted Cl(-) homeostasis contributes to reductions in the inhibitory efficacy of diazepam during hyperexcited states. The European Journal of Neuroscience. 38: 2453-67
Deeb TZ, Maguire J, Moss SJ. (2012) Possible alterations in GABAA receptor signaling that underlie benzodiazepine-resistant seizures. Epilepsia. 53: 79-88
Othman NA, Gallacher M, Deeb TZ, et al. (2012) Influences on blockade by t-butylbicyclo-phosphoro-thionate of GABA(A) receptor spontaneous gating, agonist activation and desensitization. The Journal of Physiology. 590: 163-78
Baptista-Hon DT, Deeb TZ, Othman NA, et al. (2012) The 5-HT3B subunit affects high-potency inhibition of 5-HT3 receptors by morphine. British Journal of Pharmacology. 165: 693-704
Deeb TZ, Lee HH, Walker JA, et al. (2011) Hyperpolarizing GABAergic transmission depends on KCC2 function and membrane potential. Channels (Austin, Tex.). 5: 475-81
Lee HH, Deeb TZ, Walker JA, et al. (2011) NMDA receptor activity downregulates KCC2 resulting in depolarizing GABAA receptor-mediated currents. Nature Neuroscience. 14: 736-43
Wu DF, Othman NA, Sharp D, et al. (2010) A conserved cysteine residue in the third transmembrane domain is essential for homomeric 5-HT3 receptor function. The Journal of Physiology. 588: 603-16
Deeb TZ, Sharp D, Hales TG. (2009) Direct subunit-dependent multimodal 5-hydroxytryptamine3 receptor antagonism by methadone. Molecular Pharmacology. 75: 908-17
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