Timothy J. Mitchison

Affiliations:

Systems Biology

Harvard Medical School, Boston, MA, United States

Area:

Microtubules, Actin, Mitosis, Cell cycle

Website:

http://www.hms.harvard.edu/dms/bbs/fac/Mitchison.php

Google:

"Timothy J. Mitchison"

Bio:

http://mitchison.med.harvard.edu/Tim_page.html
https://sysbio.med.harvard.edu/facultys/timothy-j-mitchison-phd
http://www.fas.harvard.edu/~biophys/Timothy_J_Mitchison.htm
Discovered microtubule dynamic instability.
Tim Mitchison obtained a biochemistry degree at Oxford University, UK, and then moved to the laboratory of Marc Kirschner for his Ph.D. thesis, during which he purified tubulin from centrosomes and characterized the ‘dynamic instability’ that underlies microtubule growth. He started his own group at the University of California, San Francisco (UCSF), USA, in 1988 and 9 years later moved to the systems biology department at Harvard Medical School, Boston, Massachusetts, USA. He became the President of the American Society for Cell Biology in 2010.

Cross-listing: Chemistry Tree

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Parents

Marc W. Kirschner	grad student	1984	UCSF
(Structure and dynamics of organized microtubule arrays)

Children

Thomas U .	grad student		Harvard Medical School
Matt Welch	grad student		UCSF
Julie Theriot	grad student	1993	UCSF
Narat J. Eungdamrong	grad student	2002	Harvard
Michele Shirasu-Hiza	grad student	2003	UCSF
Zoltan Maliga	grad student	2004	Harvard
David T. Miyamoto	grad student	2004	Harvard
Justin C. Yarrow	grad student	2004	Harvard
Zachary E. Perlman	grad student	2005	Harvard
Alina M. Vrabioiu	grad student	2006	Harvard
Aaron C. Groen	grad student	2008	Harvard
Hao Y. Kueh	grad student	2008	Harvard
Hsiao-Chun Huang	grad student	2010	Harvard
Martin Wühr	grad student	2005-2010	Harvard
Chi-Kuo Hu	grad student	2011	Harvard
Nefeli E. Georgoulia	grad student	2014	Harvard
Arshad Desai	post-doc		UCSF
Tarun Kapoor	post-doc		Harvard Medical School
Thomas U. Mayer	post-doc
Yuyu Song	post-doc		Harvard (Neurotree)
Jack Taunton	post-doc		Harvard Medical School (Chemistry Tree)
Yixian Zheng	post-doc		UCSF
Ivana Gasic	post-doc	2016-	Harvard Medical School
Xiang Deng	post-doc	2017-	Harvard Medical School
Tae Yeon Yoo	post-doc	2018-	Harvard Medical School
Anthony Hyman	post-doc	1993	UCSF
Tatsuya Hirano	post-doc	1989-1995	UCSF
Claire Ellen Walczak	post-doc	1998	UCSF (Chemistry Tree)
R. Scott Lokey	post-doc	2002	Harvard Medical School (Chemistry Tree)
Aaron F. Straight	post-doc	2004	Harvard Medical School
Ulrike S. Eggert	post-doc	2001-2006	Harvard Medical School (Chemistry Tree)
Paul Chang	post-doc	2007	Harvard Medical School (Chemistry Tree)
Daniel J. Needleman	post-doc	2005-2008	Harvard (Chemistry Tree)
Ethan C. Garner	post-doc	2012	Harvard Medical School

Collaborators

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Publications

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Yoo TY, Mitchison TJ. (2024) Quantitative comparison of nuclear transport inhibition by SARS coronavirus ORF6 reveals the importance of oligomerization. Proceedings of the National Academy of Sciences of the United States of America. 121: e2307997121
Quek RT, Hardy KS, Walker SG, et al. (2023) Screen for Modulation of Nucleocapsid Protein Condensation Identifies Small Molecules with Anti-Coronavirus Activity. Acs Chemical Biology
Van Itallie ES, Field CM, Mitchison TJ, et al. (2022) Dorsal lip maturation and initial archenteron extension depend on Wnt11 family ligands. Developmental Biology. 493: 67-79
Ng TL, Olson EJ, Yoo TY, et al. (2022) High-Content Screening and Computational Prediction Reveal Viral Genes That Suppress the Innate Immune Response. Msystems. e0146621
Yoo TY, Mitchison T. (2021) Quantification of nuclear transport inhibition by SARS-CoV-2 ORF6 using a broadly applicable live-cell dose-response pipeline. Biorxiv : the Preprint Server For Biology
Mitchison TJ, Field CM. (2021) Self-Organization of Cellular Units. Annual Review of Cell and Developmental Biology
Yoo TY, Mitchison TJ. (2021) O-GlcNAc modification of nuclear pore complexes accelerates bidirectional transport. The Journal of Cell Biology. 220
Pelletier JF, Field CM, Fuerthauer S, et al. (2020) Co-movement of astral microtubules, organelles and F-actin by dynein and actomyosin forces in frog egg cytoplasm. Elife. 9
Luthria G, Li R, Wang S, et al. (2020) In vivo microscopy reveals macrophage polarization locally promotes coherent microtubule dynamics in migrating cancer cells. Nature Communications. 11: 3521
Geisterfer ZM, Zhu DY, Mitchison TJ, et al. (2020) Microtubule Growth Rates Are Sensitive to Global and Local Changes in Microtubule Plus-End Density. Current Biology : Cb