Gareth Tibbs

Columbia University, New York, NY 
Neuroscience Biology
"Gareth Tibbs"
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Joyceadat RL, Beyer NP, Vasilopoulos G, et al. (2019) Alkylphenol inverse agonists of HCN1 gating: H-bond propensity, ring saturation and adduct geometry differentially determine efficacy and potency. Biochemical Pharmacology
Riegelhaupt PM, Tibbs GR, Goldstein PA. (2018) HCN and KChannels in Anesthetic Mechanisms Research. Methods in Enzymology. 602: 391-416
Tibbs GR, Posson DJ, Goldstein PA. (2016) Voltage-Gated Ion Channels in the PNS: Novel Therapies for Neuropathic Pain? Trends in Pharmacological Sciences
Lyashchenko AK, Redd KJ, Goldstein PA, et al. (2014) cAMP control of HCN2 channel Mg2+ block reveals loose coupling between the cyclic nucleotide-gating ring and the pore. Plos One. 9: e101236
Tibbs GR, Rowley TJ, Sanford RL, et al. (2013) HCN1 channels as targets for anesthetic and nonanesthetic propofol analogs in the amelioration of mechanical and thermal hyperalgesia in a mouse model of neuropathic pain. The Journal of Pharmacology and Experimental Therapeutics. 345: 363-73
Ying SW, Tibbs GR, Picollo A, et al. (2011) PIP2-mediated HCN3 channel gating is crucial for rhythmic burst firing in thalamic intergeniculate leaflet neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 10412-23
Rozario AO, Turbendian HK, Fogle KJ, et al. (2009) Voltage-dependent opening of HCN channels: Facilitation or inhibition by the phytoestrogen, genistein, is determined by the activation status of the cyclic nucleotide gating ring. Biochimica Et Biophysica Acta. 1788: 1939-49
Bell DC, Turbendian HK, Valley MT, et al. (2009) Probing S4 and S5 segment proximity in mammalian hyperpolarization-activated HCN channels by disulfide bridging and Cd2+ coordination. PflüGers Archiv : European Journal of Physiology. 458: 259-72
Lyashchenko AK, Tibbs GR. (2008) Ion binding in the open HCN pacemaker channel pore: fast mechanisms to shape "slow" channels. The Journal of General Physiology. 131: 227-43
Lyashchenko AK, Redd KJ, Yang J, et al. (2007) Propofol inhibits HCN1 pacemaker channels by selective association with the closed states of the membrane embedded channel core. The Journal of Physiology. 583: 37-56
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