Peter M. Broglie, Ph.D.

Affiliations: 
2010 North Carolina State University, Raleigh, NC 
Area:
Toxicology
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"Peter Broglie"
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Robert C. Smart grad student 2010 NCSU
 (The role of TAK1 associated binding protein 2 (TAB2) in tumor necrosis factor signaling and cell death.)
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Publications

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Morioka S, Broglie P, Omori E, et al. (2014) TAK1 kinase switches cell fate from apoptosis to necrosis following TNF stimulation. The Journal of Cell Biology. 204: 607-23
Zhou X, Gao X, Broglie PM, et al. (2014) Hexa-acylated lipid A is required for host inflammatory response to Neisseria gonorrhoeae in experimental gonorrhea. Infection and Immunity. 82: 184-92
Holzinger D, Gieldon L, Mysore V, et al. (2012) Staphylococcus aureus Panton-Valentine leukocidin induces an inflammatory response in human phagocytes via the NLRP3 inflammasome. Journal of Leukocyte Biology. 92: 1069-81
Taxman DJ, Swanson KV, Broglie PM, et al. (2012) Porphyromonas gingivalis mediates inflammasome repression in polymicrobial cultures through a novel mechanism involving reduced endocytosis. The Journal of Biological Chemistry. 287: 32791-9
Kebaier C, Chamberland RR, Allen IC, et al. (2012) Staphylococcus aureus α-hemolysin mediates virulence in a murine model of severe pneumonia through activation of the NLRP3 inflammasome. The Journal of Infectious Diseases. 205: 807-17
Broglie P, Matsumoto K, Akira S, et al. (2010) Transforming growth factor beta-activated kinase 1 (TAK1) kinase adaptor, TAK1-binding protein 2, plays dual roles in TAK1 signaling by recruiting both an activator and an inhibitor of TAK1 kinase in tumor necrosis factor signaling pathway. The Journal of Biological Chemistry. 285: 2333-9
Prickett TD, Ninomiya-Tsuji J, Broglie P, et al. (2008) TAB4 stimulates TAK1-TAB1 phosphorylation and binds polyubiquitin to direct signaling to NF-kappaB. The Journal of Biological Chemistry. 283: 19245-54
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