Genevieve S. Griffiths, Ph.D.

Affiliations: 
2007 Department of Biological Sciences University of Delaware, Newark, DE, United States 
Area:
Molecular Biology, Genetics, Cell Biology
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"Genevieve Griffiths"
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Deni S. Galileo grad student 2007 University of Delaware
 (Investigating the impact and mechanism of vesicular and non-vesicular mediated GPI-linked protein transfer from reproductive luminal fluids to sperm, using SPAM1 as a model.)
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Publications

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Reese KL, Aravindan RG, Griffiths GS, et al. (2010) Acidic hyaluronidase activity is present in mouse sperm and is reduced in the absence of SPAM1: evidence for a role for hyaluronidase 3 in mouse and human sperm. Molecular Reproduction and Development. 77: 759-72
Griffiths GS, Galileo DS, Aravindan RG, et al. (2009) Clusterin facilitates exchange of glycosyl phosphatidylinositol-linked SPAM1 between reproductive luminal fluids and mouse and human sperm membranes. Biology of Reproduction. 81: 562-70
Griffiths GS, Galileo DS, Reese K, et al. (2008) Investigating the role of murine epididymosomes and uterosomes in GPI-linked protein transfer to sperm using SPAM1 as a model. Molecular Reproduction and Development. 75: 1627-36
Griffiths GS, Miller KA, Galileo DS, et al. (2008) Murine SPAM1 is secreted by the estrous uterus and oviduct in a form that can bind to sperm during capacitation: acquisition enhances hyaluronic acid-binding ability and cumulus dispersal efficiency. Reproduction (Cambridge, England). 135: 293-301
Grigorieva A, Griffiths GS, Zhang H, et al. (2007) Expression of SPAM1 (PH-20) in the murine kidney is not accompanied by hyaluronidase activity: evidence for potential roles in fluid and water reabsorption. Kidney & Blood Pressure Research. 30: 145-55
Chen H, Griffiths G, Galileo DS, et al. (2006) Epididymal SPAM1 is a marker for sperm maturation in the mouse. Biology of Reproduction. 74: 923-30
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