Chung-Chin Kuo, M.D./Ph.D.

Physiology National Taiwan University, Taipei, Taipei City, Taiwan 
Sodium channels
"Chung-Chin Kuo"
Mean distance: 14.56 (cluster 11)
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Lin YC, Lai YC, Lin TH, et al. (2022) Selective stabilization of the intermediate inactivated Na channel by the new-generation anticonvulsant rufinamide. Biochemical Pharmacology. 197: 114928
Peng YS, Wu HT, Lai YC, et al. (2020) Inhibition of neuronal Na currents by lacosamide: Differential binding affinity and kinetics to different inactivated states. Neuropharmacology. 108266
Chen YS, Tu YC, Lai YC, et al. (2019) Desensitization of NMDA channels requires ligand binding to both GluN1 and GluN2 subunits to constrict the pore beside the activation gate. Journal of Neurochemistry. e14939
Huang CW, Lai HJ, Huang PY, et al. (2019) Anomalous enhancement of resurgent Na currents at high temperatures by SCN9A mutations underlies the episodic heat-enhanced pain in inherited erythromelalgia. Scientific Reports. 9: 12251
Lo YC, Kuo CC. (2019) Temperature dependence of the biophysical mechanisms underlying the apt inhibition and enhancement effect of amiodarone on hERG channels. Molecular Pharmacology
Tu YC, Yang YC, Kuo CC. (2016) Modulation of NMDA channel gating by Ca(2+) and Cd(2+) binding to the external pore mouth. Scientific Reports. 6: 37029
Huang CW, Lai HJ, Huang PY, et al. (2016) The Biophysical Basis Underlying Gating Changes in the p.V1316A Mutant Nav1.7 Channel and the Molecular Pathogenesis of Inherited Erythromelalgia. Plos Biology. 14: e1002561
Huang CW, Kuo CC. (2016) A synergistic blocking effect of Mg(2+) and spermine on the inward rectifier K(+) (Kir2.1) channel pore. Scientific Reports. 6: 21493
Hsieh CP, Kuo CC, Huang CW. (2015) Driving force-dependent block by internal Ba(2+) on the Kir2.1 channel: Mechanistic insight into inward rectification. Biophysical Chemistry. 202: 40-57
Huang CW, Kuo CC. (2015) Flow- and voltage-dependent blocking effect of ethosuximide on the inward rectifier K(+) (Kir2.1) channel. PflüGers Archiv : European Journal of Physiology. 467: 1733-46
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