Christopher M. Flores

Affiliations: 
University of Minnesota, Twin Cities, Minneapolis, MN 
Area:
pain, nicotine
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"Christopher Flores"
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SNBCP

Parents

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Ken J. Kellar grad student 1988-1992 Georgetown
Harold Gainer post-doc 1992-1994 NIH
Ken M. Hargreaves post-doc 1994-1997 UMN
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Publications

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Parsons WH, Calvo RR, Cheung W, et al. (2015) Benzo[d]imidazole Transient Receptor Potential Vanilloid 1 Antagonists for the Treatment of Pain: Discovery of trans-2-(2-{2-[2-(4-Trifluoromethyl-phenyl)-vinyl]-1H-benzimidazol-5-yl}-phenyl)-propan-2-ol (Mavatrep). Journal of Medicinal Chemistry. 58: 3859-74
Douglass JD, Zhou YX, Wu A, et al. (2015) Global deletion of MGL in mice delays lipid absorption and alters energy homeostasis and diet-induced obesity. Journal of Lipid Research. 56: 1153-71
Winters MP, Subasinghe N, Wall M, et al. (2014) Discovery and SAR of a novel series of 2,4,5,6-tetrahydrocyclopenta[c]pyrazoles as N-type calcium channel inhibitors. Bioorganic & Medicinal Chemistry Letters. 24: 2057-61
Winters MP, Subasinghe N, Wall M, et al. (2014) Discovery and SAR of novel tetrahydropyrrolo[3,4-c]pyrazoles as inhibitors of the N-type calcium channel. Bioorganic & Medicinal Chemistry Letters. 24: 2053-6
Feketa VV, Zhang Y, Cao Z, et al. (2014) Transient receptor potential melastatin 8 channel inhibition potentiates the hypothermic response to transient receptor potential vanilloid 1 activation in the conscious mouse. Critical Care Medicine. 42: e355-63
Feketa VV, Balasubramanian A, Flores CM, et al. (2013) Shivering and tachycardic responses to external cooling in mice are substantially suppressed by TRPV1 activation but not by TRPM8 inhibition. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 305: R1040-50
Zhu B, Xia M, Xu X, et al. (2013) Arylglycine derivatives as potent transient receptor potential melastatin 8 (TRPM8) antagonists. Bioorganic & Medicinal Chemistry Letters. 23: 2234-7
Raffa RB, Buschmann H, Christoph T, et al. (2012) Mechanistic and functional differentiation of tapentadol and tramadol. Expert Opinion On Pharmacotherapy. 13: 1437-49
Subasinghe NL, Wall MJ, Winters MP, et al. (2012) A novel series of pyrazolylpiperidine N-type calcium channel blockers. Bioorganic & Medicinal Chemistry Letters. 22: 4080-3
Clemente JC, Nulton E, Nelen M, et al. (2012) Screening and characterization of human monoglyceride lipase active site inhibitors using orthogonal binding and functional assays. Journal of Biomolecular Screening. 17: 629-40
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