Ryan Jefferson Watts

Genentech, San Francisco, CA, United States 
Neurodegeneration, Blood-brian barrier
"Ryan Watts"
Mean distance: 14.77 (cluster 11)


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Liqun Luo grad student 2004 Stanford
 (Cellular and molecular mechanisms of developmental axon pruning.)


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Nga Bien-Ly post-doc Genentech
Stephen Tam post-doc Elan
Gregory B. Potter research scientist 2015-2018
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Xiong M, Jiang H, Serrano JR, et al. (2021) APOE immunotherapy reduces cerebral amyloid angiopathy and amyloid plaques while improving cerebrovascular function. Science Translational Medicine. 13
Ullman JC, Arguello A, Getz JA, et al. (2020) Brain delivery and activity of a lysosomal enzyme using a blood-brain barrier transport vehicle in mice. Science Translational Medicine. 12
Nugent AA, Lin K, van Lengerich B, et al. (2019) TREM2 Regulates Microglial Cholesterol Metabolism upon Chronic Phagocytic Challenge. Neuron
Liao F, Li A, Xiong M, et al. (2018) Targeting of nonlipidated, aggregated apoE with antibodies inhibits amyloid accumulation. The Journal of Clinical Investigation
Lee SH, Le Pichon CE, Adolfsson O, et al. (2016) Antibody-Mediated Targeting of Tau In Vivo Does Not Require Effector Function and Microglial Engagement. Cell Reports
Lu Y, Hoyte K, Montgomery WH, et al. (2016) Characterization of a sensitive mouse Aβ40 PD biomarker assay for Alzheimer's disease drug development in wild-type mice. Bioanalysis
Gadkar K, Yadav DB, Zuchero JY, et al. (2016) Mathematical PKPD and safety model of bispecific TfR/BACE1 antibodies for the optimization of antibody uptake in brain. European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Fur Pharmazeutische Verfahrenstechnik E.V
Zuchero YJ, Chen X, Bien-Ly N, et al. (2015) Discovery of Novel Blood-Brain Barrier Targets to Enhance Brain Uptake of Therapeutic Antibodies. Neuron
Bien-Ly N, Boswell CA, Jeet S, et al. (2015) Lack of Widespread BBB Disruption in Alzheimer's Disease Models: Focus on Therapeutic Antibodies. Neuron. 88: 289-97
Fuji RN, Flagella M, Baca M, et al. (2015) Effect of selective LRRK2 kinase inhibition on nonhuman primate lung. Science Translational Medicine. 7: 273ra15
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