Ryan Jefferson Watts
Affiliations: | Genentech, Inc., San Francisco, CA, United States |
Area:
Neurodegeneration, Blood-brian barrierGoogle:
"Ryan Watts"Mean distance: 14.77 (cluster 11) | S | N | B | C | P |
Parents
Sign in to add mentorChildren
Sign in to add trainee| Nga Bien-Ly | post-doc | Genentech, Inc. | |
| Stephen Tam | post-doc | Elan | |
| Gregory B. Potter | research scientist | 2015-2018 |
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Publications
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| Xiong M, Jiang H, Serrano JR, et al. (2021) APOE immunotherapy reduces cerebral amyloid angiopathy and amyloid plaques while improving cerebrovascular function. Science Translational Medicine. 13 |
| Kariolis MS, Wells RC, Getz JA, et al. (2020) Brain delivery of therapeutic proteins using an Fc fragment blood-brain barrier transport vehicle in mice and monkeys. Science Translational Medicine. 12 |
| Ullman JC, Arguello A, Getz JA, et al. (2020) Brain delivery and activity of a lysosomal enzyme using a blood-brain barrier transport vehicle in mice. Science Translational Medicine. 12 |
| Nugent AA, Lin K, van Lengerich B, et al. (2019) TREM2 Regulates Microglial Cholesterol Metabolism upon Chronic Phagocytic Challenge. Neuron |
| Henry AG, Kariolis MS, Ullman JC, et al. (2019) Improved brain uptake and efficacy of iduronate 2-sulfatase with the enzyme transport vehicle Molecular Genetics and Metabolism. 126: S72 |
| Liao F, Li A, Xiong M, et al. (2018) Targeting of nonlipidated, aggregated apoE with antibodies inhibits amyloid accumulation. The Journal of Clinical Investigation |
| Bumbaca Yadav D, Maloney JA, Wildsmith KR, et al. (2017) Widespread brain distribution and activity following anti-BACE1 intracerebroventricular infusion in nonhuman primates. British Journal of Pharmacology |
| Lo M, Kim HS, Tong RK, et al. (2017) Effector attenuating substitutions that maintain antibody stability and reduce toxicity in mice. The Journal of Biological Chemistry |
| Lee SH, Le Pichon CE, Adolfsson O, et al. (2016) Antibody-Mediated Targeting of Tau In Vivo Does Not Require Effector Function and Microglial Engagement. Cell Reports |
| Gadkar K, Yadav DB, Zuchero JY, et al. (2016) Mathematical PKPD and safety model of bispecific TfR/BACE1 antibodies for the optimization of antibody uptake in brain. European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Fur Pharmazeutische Verfahrenstechnik E.V |