Alem Kahsai
Affiliations: | University of Connecticut, Storrs, CT, United States |
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Parents
Sign in to add mentorGabriel Fenteany | grad student | University of Connecticut | |
Robert J. Lefkowitz | research scientist | Duke |
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Publications
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Kahsai AW, Shah KS, Shim PJ, et al. (2023) Signal transduction at GPCRs: Allosteric activation of the ERK MAPK by β-arrestin. Proceedings of the National Academy of Sciences of the United States of America. 120: e2303794120 |
Ahn S, Maarsingh H, Walker JK, et al. (2023) Allosteric modulator potentiates β2AR agonist-promoted bronchoprotection in asthma models. The Journal of Clinical Investigation |
Asher WB, Terry DS, Gregorio GGA, et al. (2022) GPCR-mediated β-arrestin activation deconvoluted with single-molecule precision. Cell |
Zang Y, Kahsai AW, Pakharukova N, et al. (2021) The GPCR-β-arrestin complex allosterically activates C-Raf by binding its amino-terminus. The Journal of Biological Chemistry. 101369 |
Pani B, Ahn S, Rambarat PK, et al. (2021) . Molecular Pharmacology |
Wang J, Pani B, Gokhan I, et al. (2021) β-arrestin-biased allosteric modulator potentiates Carvedilol stimulated β adrenergic receptor cardioprotection. Molecular Pharmacology |
Smith JS, Pack TF, Inoue A, et al. (2021) Noncanonical scaffolding of G and β-arrestin by G protein-coupled receptors. Science (New York, N.Y.) |
Liu Q, He QT, Lyu X, et al. (2020) DeSiphering receptor core-induced and ligand-dependent conformational changes in arrestin via genetic encoded trimethylsilyl H-NMR probe. Nature Communications. 11: 4857 |
Liu X, Masoudi A, Kahsai AW, et al. (2019) Mechanism of βAR regulation by an intracellular positive allosteric modulator. Science (New York, N.Y.). 364: 1283-1287 |
Kahsai AW, Pani B, Lefkowitz RJ. (2018) GPCR signaling: conformational activation of arrestins. Cell Research |