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Jonathan B. Cohen, Ph.D.

Affiliations: 
Massachusetts General Hospital, Boston, MA 
 1975-1982 Pharmacology Harvard Medical School, Boston, MA, United States 
 1982-1992 Anatomy and Neurobiology Washington University School of Medicine, St. Louis, MO, United States 
 1992- Neurobiology Harvard Medical School, Boston, MA, United States 
Area:
nicotinic acetylcholine receptors (AChR) and GABAa receptors
Website:
http://www.fas.harvard.edu/~biophys/Jonathan_B_Cohen.htm
Google:
"Jonathan B. Cohen"
Bio:

http://www.hms.harvard.edu/dms/neuroscience/fac/cohen.php
http://www.hms.harvard.edu/bss/neuro/cohen/
http://neuro.med.harvard.edu/faculty/cohen.html

Mean distance: 13.68 (cluster 11)
 
SNBCP
Cross-listing: Chemistry Tree

Parents

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Edgar Bright Wilson, Jr. grad student 1972 Harvard (Chemistry Tree)
 (Microwave-microwave double resonance investigations of collisional transfer of rotational energy)
Jean-Pierre Changeux post-doc Institut Pasteur

Children

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Richard Neubig grad student 1980 Harvard Medical School
Marcus L. Ware grad student 2000 Harvard
Jonathan C. Trinidad grad student 2003 Harvard
Michael J. Bianchetta grad student 2004 Harvard
Filbert H. Hong grad student 2004 Harvard
Laura M. Magnotti grad student 2010 Harvard
Steen E. Pedersen post-doc 1984-1989 Washington University
Marc Bartoli post-doc 1999-2001 Harvard Medical School
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Publications

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Jayakar SS, Zhou X, Chiara DC, et al. (2019) Identifying drugs that bind selectively to intersubunit general anesthetic sites in the α1β3γ2 GABAR transmembrane domain. Molecular Pharmacology
Yu Z, Chiara DC, Savechenkov PY, et al. (2019) A photoreactive analog of allopregnanolone enables identification of steroid-binding sites in a nicotinic acetylcholine receptor. The Journal of Biological Chemistry
Wu B, Jayakar SS, Zhou X, et al. (2018) Inhibitable photolabeling by neurosteroid diazirine analog in the β3-Subunit of human hetereopentameric type A GABA receptors. European Journal of Medicinal Chemistry. 162: 810-824
McGrath M, Yu Z, Jayakar SS, et al. (2018) Etomidate and Etomidate Analog Binding and Positive Modulation of γ-Aminobutyric Acid Type A Receptors: Evidence for a State-dependent Cutoff Effect. Anesthesiology
Ma C, Pejo E, McGrath M, et al. (2017) Competitive Antagonism of Anesthetic Action at the γ-Aminobutyric Acid Type A Receptor by a Novel Etomidate Analog with Low Intrinsic Efficacy. Anesthesiology
Savechenkov PY, Chiara DC, Desai R, et al. (2017) Synthesis and pharmacological evaluation of neurosteroid photoaffinity ligands. European Journal of Medicinal Chemistry. 136: 334-347
Chiara DC, Jounaidi Y, Zhou X, et al. (2016) General Anesthetic Binding Sites in Human α4β3δ γ-Aminobutyric Acid Type-A Receptors (GABAAR). The Journal of Biological Chemistry
Jayakar SS, Zhou X, Savechenkov PY, et al. (2015) Positive and Negative Allosteric Modulation of an α1β3γ2 γ-Aminobutyric acid Type A (GABAA) Receptor by Binding to a Site in the Transmembrane Domain at the γ+-β- Interface. The Journal of Biological Chemistry
Hamouda AK, Wang ZJ, Stewart DS, et al. (2015) Desformylflustrabromine (dFBr) and [3H]dFBr-Labeled Binding Sites in a Nicotinic Acetylcholine Receptor. Molecular Pharmacology. 88: 1-11
Jayakar SS, Zhou X, Chiara DC, et al. (2014) Multiple propofol-binding sites in a γ-aminobutyric acid type A receptor (GABAAR) identified using a photoreactive propofol analog. The Journal of Biological Chemistry. 289: 27456-68
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