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Narasimhan Gautam, Ph.D.

Affiliations: 
Anesthesiology Washington University Medical School 
Area:
G-proteins
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"Narasimhan Gautam"
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Parents

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Melvin I. Simon post-doc Caltech (Chemistry Tree)

Children

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Gerald Brian Downes grad student 1992-1999 Washington University

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Publications

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Meshik X, O'Neill PR, Gautam N. (2018) Optogenetic Control of Cell Migration. Methods in Molecular Biology (Clifton, N.J.). 1749: 313-324
O'Neill PR, Kalyanaraman V, Gautam N. (2016) Subcellular optogenetic activation of Cdc42 controls local and distal signaling to drive immune cell migration. Molecular Biology of the Cell
O'Neill PR, Gautam N. (2015) Optimizing optogenetic constructs for control over signaling and cell behaviours. Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society For Photobiology. 14: 1578-85
Karunarathne WK, O'Neill PR, Gautam N. (2015) Subcellular optogenetics - controlling signaling and single-cell behavior. Journal of Cell Science. 128: 15-25
Giri L, Patel AK, Karunarathne WK, et al. (2014) A G-protein subunit translocation embedded network motif underlies GPCR regulation of calcium oscillations. Biophysical Journal. 107: 242-54
O'Neill PR, Gautam N. (2014) Subcellular optogenetic inhibition of G proteins generates signaling gradients and cell migration. Molecular Biology of the Cell. 25: 2305-14
O'Neill PR, Giri L, Karunarathne WK, et al. (2014) The structure of dynamic GPCR signaling networks. Wiley Interdisciplinary Reviews. Systems Biology and Medicine. 6: 115-23
Karunarathne WK, Giri L, Patel AK, et al. (2013) Optical control demonstrates switch-like PIP3 dynamics underlying the initiation of immune cell migration. Proceedings of the National Academy of Sciences of the United States of America. 110: E1575-83
Karunarathne WK, Giri L, Kalyanaraman V, et al. (2013) Optically triggering spatiotemporally confined GPCR activity in a cell and programming neurite initiation and extension. Proceedings of the National Academy of Sciences of the United States of America. 110: E1565-74
O'Neill PR, Karunarathne WK, Kalyanaraman V, et al. (2012) G-protein signaling leverages subunit-dependent membrane affinity to differentially control βγ translocation to intracellular membranes. Proceedings of the National Academy of Sciences of the United States of America. 109: E3568-77
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