Ronald A. Bush

National Eye Institute, Bethesda, Maryland 
visual system, retina, genetics, retinal degeneration, gene therapy
"Ronald Bush"
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Zeng Y, Qian H, Wu Z, et al. (2019) AAVrh-10 transduces outer retinal cells in rodents and rabbits following intravitreal administration. Gene Therapy
Song H, Bush RA, Zeng Y, et al. (2019) Trans-ocular Electric Current Enhances AAV-Mediated Retinal Gene Transduction after Intravitreal Vector Administration. Molecular Therapy. Methods & Clinical Development. 13: 77-85
Cukras C, Wiley HE, Jeffrey BG, et al. (2018) Retinal AAV8-RS1 Gene Therapy for X-Linked Retinoschisis: Initial Findings from a Phase I/IIa Trial by Intravitreal Delivery. Molecular Therapy : the Journal of the American Society of Gene Therapy. 26: 2282-2294
Marangoni D, Yong Z, Kjellström S, et al. (2017) Rearing Light Intensity Affects Inner Retinal Pathology in a Mouse Model of X-Linked Retinoschisis but Does Not Alter Gene Therapy Outcome. Investigative Ophthalmology & Visual Science. 58: 1656-1664
Marangoni D, Bush RA, Zeng Y, et al. (2016) Ocular and systemic safety of a recombinant AAV8 vector for X-linked retinoschisis gene therapy: GLP studies in rabbits and Rs1-KO mice. Molecular Therapy. Methods & Clinical Development. 5: 16011
Zeng Y, Petralia RS, Vijayasarathy C, et al. (2016) Retinal Structure and Gene Therapy Outcome in Retinoschisin-Deficient Mice Assessed by Spectral-Domain Optical Coherence Tomography. Investigative Ophthalmology & Visual Science. 57: OCT277-OCT287
Song H, Vijayasarathy C, Zeng Y, et al. (2016) NADPH Oxidase Contributes to Photoreceptor Degeneration in Constitutively Active RAC1 Mice. Investigative Ophthalmology & Visual Science. 57: 2864-2875
Bush RA, Zeng Y, Colosi P, et al. (2016) Preclinical Dose Escalation Study of Intravitreal AAV-RS1 Gene Therapy in a Mouse Model of X-linked Retinoschisis: Dose-Dependent Expression and Improved Retinal Structure and Function. Human Gene Therapy
Marangoni D, Vijayasarathy C, Bush RA, et al. (2015) Intravitreal Ciliary Neurotrophic Factor Transiently Improves Cone-Mediated Function in a CNGB3-/- Mouse Model of Achromatopsia. Investigative Ophthalmology & Visual Science. 56: 6810-6822
Bush RA, Wei LL, Sieving PA. (2015) Convergence of Human Genetics and Animal Studies: Gene Therapy for X-Linked Retinoschisis. Cold Spring Harbor Perspectives in Medicine
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