Benoit I. Giasson, Ph.D.

Pharmacology University of Pennsylvania, Philadelphia, PA, United States 
 Neuroscience University of Florida, Gainesville, Gainesville, FL, United States 
Neurodegeneration ,Parkinson’s disease, Neuronal Damage, Protein Aggregation,Kinases, Alpha-synuclein, Tau
"Benoit Giasson"

Post-Doc, Pathology and Laboratory Medicine (John Trojanowski), University of Pennsylvania, 2001-2003
Post-Doc, Pathology and Laboratory Medicine (Virginia Lee), University of Pennsylvania, 1998-2001
Ph.D., Biochemistry, McGill University, Canada- 1997

My research is focused on understanding the cellular mechanisms and molecular interactions involved as underlying causes of neurodegenerative diseases. A primary research interest is to expand the understanding of the regulation of protein levels, function, interactions and folding that affect protein aggregation in the nervous system.

Mean distance: 15.49 (cluster 24)
Cross-listing: Chemistry Tree


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Walter E. Mushynski grad student 1991-1997 McGill
Virginia Man-Yee Lee post-doc 1998-2001 Penn
John Q. Trojanowski post-doc 2001-2003 Penn


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Jason P. Covy grad student 2004-2010 Penn
Chenere P. Ramsey grad student 2004-2010 Penn
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Lloyd GM, Dhillon JS, Gorion KM, et al. (2021) Collusion of α-Synuclein and Aβ aggravating co-morbidities in a novel prion-type mouse model. Molecular Neurodegeneration. 16: 63
Hass EW, Sorrentino ZA, Xia Y, et al. (2021) Disease-, region- and cell type specific diversity of α-synuclein carboxy terminal truncations in synucleinopathies. Acta Neuropathologica Communications. 9: 146
Xia Y, Bell BM, Giasson BI. (2021) Tau K321/K353 pseudoacetylation within KXGS motifs regulates tau-microtubule interactions and inhibits aggregation. Scientific Reports. 11: 17069
Dagra A, Miller DR, Lin M, et al. (2021) α-Synuclein-induced dysregulation of neuronal activity contributes to murine dopamine neuron vulnerability. Npj Parkinson's Disease. 7: 76
Ferreira N, Richner M, van der Laan A, et al. (2021) Prodromal neuroinvasion of pathological α-synuclein in brainstem reticular nuclei and white matter lesions in a model of α-synucleinopathy. Brain Communications. 3: fcab104
Xia Y, Prokop S, Giasson BI. (2021) "Don't Phos Over Tau": recent developments in clinical biomarkers and therapies targeting tau phosphorylation in Alzheimer's disease and other tauopathies. Molecular Neurodegeneration. 16: 37
Ferreira N, Gram H, Sorrentino ZA, et al. (2021) Multiple system atrophy-associated oligodendroglial protein p25α stimulates formation of novel α-synuclein strain with enhanced neurodegenerative potential. Acta Neuropathologica
Hass EW, Sorrentino ZA, Lloyd GM, et al. (2021) Robust α-synuclein pathology in select brainstem neuronal populations is a potential instigator of multiple system atrophy. Acta Neuropathologica Communications. 9: 80
Krumm ZA, Lloyd GM, Francis CP, et al. (2021) Precision therapeutic targets for COVID-19. Virology Journal. 18: 66
Xia Y, Nasif L, Giasson BI. (2021) Pathogenic MAPT mutations Q336H and Q336R have isoform-dependent differences in aggregation propensity and microtubule dysfunction. Journal of Neurochemistry
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