Jianfu Chen, Ph.D.

Affiliations: 
2008 Cell & Developmental Biology University of North Carolina, Chapel Hill, Chapel Hill, NC 
Area:
Cell Biology
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"Jianfu Chen"

Parents

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Lee Niswander grad student University of Colorado, Denver (Neurotree)
Da-Zhi Wang grad student 2008 UNC Chapel Hill
 (MicroRNA function in muscle development.)
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Publications

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Zhang W, Ma L, Yang M, et al. (2020) Cerebral organoid and mouse models reveal a RAB39b-PI3K-mTOR pathway-dependent dysregulation of cortical development leading to macrocephaly/autism phenotypes. Genes & Development
Liang C, Shao Q, Zhang W, et al. (2020) Smcr8 deficiency disrupts axonal transport-dependent lysosomal function and promotes axonal swellings and gain of toxicity in C9ALS/FTD mouse models. Human Molecular Genetics
Shao Q, Yang M, Liang C, et al. (2019) and mutant mice reveal MTORC1 activation due to impaired lysosomal degradation and exocytosis. Autophagy
Liang C, Shao Q, Zhang W, et al. (2019) Smcr8 deficiency disrupts axonal transport-dependent lysosomal function and promotes axonal swellings and gain of toxicity in C9ALS/FTD mouse models. Human Molecular Genetics
Zhang W, Yang SL, Yang M, et al. (2019) Modeling microcephaly with cerebral organoids reveals a WDR62-CEP170-KIF2A pathway promoting cilium disassembly in neural progenitors. Nature Communications. 10: 2612
Herrlinger S, Shao Q, Yang M, et al. (2019) Lin28-mediated promotion of protein synthesis is critical for neural progenitor cell maintenance and brain development in mice. Development (Cambridge, England)
Gao F, Kataoka M, Liu N, et al. (2019) Therapeutic role of miR-19a/19b in cardiac regeneration and protection from myocardial infarction. Nature Communications. 10: 1802
Shao Q, Liang C, Chang Q, et al. (2019) C9orf72 deficiency promotes motor deficits of a C9ALS/FTD mouse model in a dose-dependent manner. Acta Neuropathologica Communications. 7: 32
Herrlinger SA, Shao Q, Ma L, et al. (2018) Establishing Mouse Models for Zika Virus-induced Neurological Disorders Using Intracerebral Injection Strategies: Embryonic, Neonatal, and Adult. Journal of Visualized Experiments : Jove
Dong K, Guo X, Chen W, et al. (2018) Mesenchyme Homeobox 1 mediates transforming growth factor-β (TGF-β)-induced smooth muscle cell differentiation from mouse mesenchymal progenitors. The Journal of Biological Chemistry
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