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John R. Vane, Ph.D.

Wellcome Foundation 
Platelets, prostaglandins
"John R. Vane"

(1927 - 2004)
The Nobel Prize in Physiology or Medicine 1982 was awarded jointly to Sune K. Bergström, Bengt I. Samuelsson and John R. Vane "for their discoveries concerning prostaglandins and related biologically active substances".

Mean distance: 19.28 (cluster 3)
Cross-listing: Chemistry Tree


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J Harold Burn research assistant 1946-1950 Oxford
Geoffrey S. Dawes grad student 1953 Oxford


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Daniela Salvemini grad student London University (Anatomy Tree)
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Simmons DL, Botting RM, Robertson PM, et al. (1999) Induction of an acetaminophen-sensitive cyclooxygenase with reduced sensitivity to nonsteroid antiinflammatory drugs. Proceedings of the National Academy of Sciences of the United States of America. 96: 3275-80
Swierkosz TA, Mitchell JA, Warner TD, et al. (1995) Co-induction of nitric oxide synthase and cyclo-oxygenase: Interactions between nitric oxide and prostanoids British Journal of Pharmacology. 114: 1335-1342
Swierkosz TA, Warner TD, Vane JR. (1995) NG-Hydroxy-L-Arginine Releases from Endothelial Cells Nitric Oxide which Increases cGMP in RFL-6 Fibroblasts Endothelium. 3: 121-129
Pistelli A, Mollace V, Nistico G, et al. (1994) Nitroblue tetrazolium inhibits oxidation of glyceryl trinitrate to nitric oxide in bovine aortic smooth muscle cells Biochemical Pharmacology. 47: 1737-1742
Macarthur H, Warner TD, Wood EG, et al. (1994) Endothelin-1 Release from Endothelial Cells in Culture Is Elevated Both Acutely and Chronically by Short Periods of Mechanical Stretch Biochemical and Biophysical Research Communications. 200: 395-400
Desai KM, Warner TD, Bishop AE, et al. (1994) Nitric oxide, and not vasoactive intestinal peptide, as the main neurotransmitter of vagally induced relaxation of the guinea pig stomach British Journal of Pharmacology. 113: 1197-1202
Szabó C, Southan GJ, Thiemermann C, et al. (1994) The mechanism of the inhibitory effect of polyamines on the induction of nitric oxide synthase: role of aldehyde metabolites. British Journal of Pharmacology. 113: 757-766
Szabó C, Southan GJ, Wood E, et al. (1994) Inhibition by spermine of the induction of nitric oxide synthase in J774.2 macrophages : requirement of a serum factor British Journal of Pharmacology. 112: 355-356
Korbut I, Warner TD, Gryglewski RJ, et al. (1994) The effect of nitric oxide synthase inhibition on the plasma fibrinolytic system in septic shock in rats British Journal of Pharmacology. 112: 289-291
Wood PJ, Stratford IJ, Adams GE, et al. (1993) Modification of energy metabolism and radiation response of a murine tumour by changes in nitric oxide availability. Biochemical and Biophysical Research Communications. 192: 505-10
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