Edward L. Briercheck, Ph.D.

Affiliations: 
2013 Integrated Biomedical Science Graduate Program Ohio State University, Columbus, Columbus, OH 
Area:
Medicine and Surgery, Immunology, Cell Biology, Oncology
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"Edward Briercheck"

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Michael A. Caligiuri grad student 2013 Ohio State
 (Elucidation of the Mechanism by which Phosphatase and Tensin Homologue Deleted on Chromosome Ten (PTEN) Regulates Natural Killer Cell Function.)
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Publications

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Mundy-Bosse BL, Weigel C, Wu YZ, et al. (2022) Identification and Targeting of the Developmental Blockade in Extranodal Natural Killer/T-cell Lymphoma. Blood Cancer Discovery. 3: 154-169
Victor AR, Nalin AP, Dong W, et al. (2017) IL-18 Drives ILC3 Proliferation and Promotes IL-22 Production via NF-κB. Journal of Immunology (Baltimore, Md. : 1950)
Elavazhagan S, Fatehchand K, Santhanam V, et al. (2015) Granzyme B expression is enhanced in human monocytes by TLR8 agonists and contributes to antibody-dependent cellular cytotoxicity. Journal of Immunology (Baltimore, Md. : 1950). 194: 2786-95
Briercheck EL, Trotta R, Chen L, et al. (2015) PTEN is a negative regulator of NK cell cytolytic function. Journal of Immunology (Baltimore, Md. : 1950). 194: 1832-40
Hughes T, Briercheck EL, Freud AG, et al. (2014) The transcription Factor AHR prevents the differentiation of a stage 3 innate lymphoid cell subset to natural killer cells. Cell Reports. 8: 150-62
Collins SM, Bakan CE, Swartzel GD, et al. (2013) Elotuzumab directly enhances NK cell cytotoxicity against myeloma via CS1 ligation: evidence for augmented NK cell function complementing ADCC. Cancer Immunology, Immunotherapy : Cii. 62: 1841-9
Trotta R, Chen L, Costinean S, et al. (2013) Overexpression of miR-155 causes expansion, arrest in terminal differentiation and functional activation of mouse natural killer cells. Blood. 121: 3126-34
McClory S, Hughes T, Freud AG, et al. (2012) Evidence for a stepwise program of extrathymic T cell development within the human tonsil. The Journal of Clinical Investigation. 122: 1403-15
Briercheck EL, Trotta R, Cole JP, et al. (2012) Human Natural Killer (NK) Cells: Differential Expression of Phosphatase and Tensin Homologue Deleted On Chromosome Ten (PTEN) During NK Cell Development Regulates Its Cytolytic Activity Against Leukemic Target Cells Blood. 120: 254-254
Trotta R, Ciarlariello D, Dal Col J, et al. (2011) The PP2A inhibitor SET regulates granzyme B expression in human natural killer cells. Blood. 117: 2378-84
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