Paul K. Brindle, Ph.D

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Wong CK, Wade-Vallance AK, Luciani DS, et al. (2017) The p300 and CBP Transcriptional Coactivators are Required for Beta Cell and Alpha Cell Proliferation. Diabetes
Carré GA, Siggers P, Xipolita M, et al. (2017) Loss of p300 and CBP disrupts histone acetylation at the mouse Sry promoter and causes XY gonadal sex reversal. Human Molecular Genetics
García-Ramírez I, Tadros S, González-Herrero I, et al. (2017) Crebbp loss cooperates with Bcl2 over-expression to promote lymphoma in mice. Blood
Zhang J, Vlasevska S, Wells VA, et al. (2017) The Crebbp Acetyltransferase is a Haploinsufficient Tumor Suppressor in B Cell Lymphoma. Cancer Discovery
Zheng F, Kasper LH, Bedford DC, et al. (2016) Mutation of the CH1 Domain in the Histone Acetyltransferase CREBBP Results in Autism-Relevant Behaviors in Mice. Plos One. 11: e0146366
Wong CK, Lynn F, Brindle P, et al. (2015) MG-135 P300 regulates glucose homeostasis by maintaining islet mass Journal of Medical Genetics. 52: A13.1-A13
Paz JC, Park S, Phillips N, et al. (2014) Combinatorial regulation of a signal-dependent activator by phosphorylation and acetylation. Proceedings of the National Academy of Sciences of the United States of America. 111: 17116-21
Kasper LH, Qu C, Obenauer JC, et al. (2014) Genome-wide and single-cell analyses reveal a context dependent relationship between CBP recruitment and gene expression. Nucleic Acids Research. 42: 11363-82
Liu Y, Wang L, Han R, et al. (2014) Two histone/protein acetyltransferases, CBP and p300, are indispensable for Foxp3+ T-regulatory cell development and function. Molecular and Cellular Biology. 34: 3993-4007
Kasper LH, Fukuyama T, Brindle PK. (2014) T-cells null for the MED23 subunit of mediator express decreased levels of KLF2 and inefficiently populate the peripheral lymphoid organs. Plos One. 9: e102076