Arthur L. Horwich

Affiliations: 
Genetics and Pediatrics Yale University, New Haven, CT 
Area:
chaperonins
Website:
http://medicine.yale.edu/labs/horwich/www/
Google:
"Arthur Horwich"
Bio:

http://www.nasonline.org/member-directory/members/2540934.html
http://news.yale.edu/2011/09/12/yales-horwich-wins-lasker-award-one-sciences-top-honors

Mean distance: 18.33 (cluster 31)
 
Cross-listing: Chemistry Tree

Parents

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Walter Eckhart post-doc Salk Institute (Chemistry Tree)

Children

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Yuyu Song post-doc Yale
Jiou Wang post-doc Yale
Jonathan S. Weissman post-doc Yale (Chemistry Tree)
Hays S. Rye post-doc 1995-2000 Yale University Medical School (Chemistry Tree)
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Publications

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Abdeen S, Kunkle T, Salim N, et al. (2018) Sulfonamido-2-arylbenzoxazole GroEL/ES inhibitors are potent antibacterials against methicillin-resistant Staphylococcus aureus (MRSA). Journal of Medicinal Chemistry
Natesh R, Clare DK, Farr GW, et al. (2018) A two-domain folding intermediate of RuBisCO in complex with the GroEL chaperonin. International Journal of Biological Macromolecules
Thomas EV, Fenton WA, McGrath J, et al. (2017) Transfer of pathogenic and nonpathogenic cytosolic proteins between spinal cord motor neurons in vivo in chimeric mice. Proceedings of the National Academy of Sciences of the United States of America
Zhang Y, Ni W, Horwich AL, et al. (2017) An ALS-associated mutant SOD1 rapidly suppresses KCNT1 (Slack) Na+-activated K+ channels in Aplysia neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience
Hadzipasic M, Ni W, Nagy M, et al. (2016) Reduced high-frequency motor neuron firing, EMG fractionation, and gait variability in awake walking ALS mice. Proceedings of the National Academy of Sciences of the United States of America
Abdeen S, Salim N, Mammadova N, et al. (2016) Targeting the HSP60/10 chaperonin systems of Trypanosoma brucei as a strategy for treating African sleeping sickness. Bioorganic & Medicinal Chemistry Letters
Abdeen S, Salim N, Mammadova N, et al. (2016) GroEL/ES inhibitors as potential antibiotics. Bioorganic & Medicinal Chemistry Letters. 26: 3127-34
Nagy M, Fenton WA, Li D, et al. (2016) Extended survival of misfolded G85R SOD1-linked ALS mice by transgenic expression of chaperone Hsp110. Proceedings of the National Academy of Sciences of the United States of America
Rosenzweig R, Farber P, Velyvis A, et al. (2015) ClpB N-terminal domain plays a regulatory role in protein disaggregation. Proceedings of the National Academy of Sciences of the United States of America
Ambrose AJ, Fenton W, Mason DJ, et al. (2015) Unfolded DapA forms aggregates when diluted into free solution, confounding comparison with folding by the GroEL/GroES chaperonin system. Febs Letters. 589: 497-9
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