Harveen Dhillon, Ph.D.

Affiliations: 
2000 University of Florida, Gainesville, Gainesville, FL, United States 
Area:
Neuroscience Biology
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Pushpa S. Kalra grad student 2000 University of Florida
 (Effects of recombinant adeno -associated virus encoding leptin on body weight regulation and energy homeostasis.)
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Publications

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Klöckener T, Hess S, Belgardt BF, et al. (2011) High-fat feeding promotes obesity via insulin receptor/PI3K-dependent inhibition of SF-1 VMH neurons. Nature Neuroscience. 14: 911-8
Xu Y, Hill JW, Fukuda M, et al. (2010) PI3K signaling in the ventromedial hypothalamic nucleus is required for normal energy homeostasis. Cell Metabolism. 12: 88-95
Hawke Z, Ivanov TR, Bechtold DA, et al. (2009) PACAP neurons in the hypothalamic ventromedial nucleus are targets of central leptin signaling. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 14828-35
Zhang R, Dhillon H, Yin H, et al. (2008) Selective inactivation of Socs3 in SF1 neurons improves glucose homeostasis without affecting body weight. Endocrinology. 149: 5654-61
Tong Q, Ye C, McCrimmon RJ, et al. (2007) Synaptic glutamate release by ventromedial hypothalamic neurons is part of the neurocircuitry that prevents hypoglycemia. Cell Metabolism. 5: 383-93
Dhillon H, Zigman JM, Ye C, et al. (2006) Leptin directly activates SF1 neurons in the VMH, and this action by leptin is required for normal body-weight homeostasis. Neuron. 49: 191-203
Bachman ES, Dhillon H, Zhang CY, et al. (2002) betaAR signaling required for diet-induced thermogenesis and obesity resistance. Science (New York, N.Y.). 297: 843-5
Beretta E, Dhillon H, Kalra PS, et al. (2002) Central LIF gene therapy suppresses food intake, body weight, serum leptin and insulin for extended periods. Peptides. 23: 975-84
Dube MG, Beretta E, Dhillon H, et al. (2002) Central leptin gene therapy blocks high-fat diet-induced weight gain, hyperleptinemia, and hyperinsulinemia: increase in serum ghrelin levels. Diabetes. 51: 1729-36
Dhillon H, Kalra SP, Kalra PS. (2001) Dose-dependent effects of central leptin gene therapy on genes that regulate body weight and appetite in the hypothalamus Molecular Therapy. 4: 139-145
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