Evan P. Lebois, PhD

Stanley Center for Psychiatric Disease Broad Institute of Harvard and MIT 
Neuroscience Drug Discovery
"Evan Lebois"
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Jeffrey P. Conn grad student Vanderbilt
Kurt L. Drickamer grad student Imperial College London (Chemistry Tree)
Allan I. Levey grad student Emory
Craig W. Lindsley grad student Vanderbilt (Chemistry Tree)
Joseph R. Manns grad student Emory
Erica Selva grad student University of Delaware


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Chun Hu research assistant 2012-2015 Emory
Leslie N. Aldrich grad student (Chemistry Tree)
Emily Doucette grad student Harvard & MIT
Matthew Hamm grad student University of Miami
Jay Li grad student University of Michigan Medical School
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Galloway CR, Ravipati K, Singh S, et al. (2018) Hippocampal place cell dysfunction and the effects of muscarinic M receptor agonism in a rat model of Alzheimer's disease. Hippocampus
Lebois EP, Schroeder JP, Esparza TJ, et al. (2017) Disease-Modifying Effects of M1 Muscarinic Acetylcholine Receptor Activation in an Alzheimer's Disease Mouse Model. Acs Chemical Neuroscience
Lebois EP, Trimper JB, Hu C, et al. (2016) Effects of selective M1 muscarinic receptor activation on hippocampal spatial representations and neuronal oscillations. Acs Chemical Neuroscience
Galloway CR, Lebois EP, Shagarabi SL, et al. (2014) Effects of selective activation of M1 and M4 muscarinic receptors on object recognition memory performance in rats. Pharmacology. 93: 57-64
Digby GJ, Utley TJ, Lamsal A, et al. (2012) Chemical modification of the M(1) agonist VU0364572 reveals molecular switches in pharmacology and a bitopic binding mode. Acs Chemical Neuroscience. 3: 1025-36
Digby GJ, Noetzel MJ, Bubser M, et al. (2012) Novel allosteric agonists of M1 muscarinic acetylcholine receptors induce brain region-specific responses that correspond with behavioral effects in animal models. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 8532-44
Melancon BJ, Gogliotti RD, Tarr JC, et al. (2012) Continued optimization of the MLPCN probe ML071 into highly potent agonists of the hM1 muscarinic acetylcholine receptor. Bioorganic & Medicinal Chemistry Letters. 22: 3467-72
Lebois EP, Digby GJ, Sheffler DJ, et al. (2011) Development of a highly selective, orally bioavailable and CNS penetrant M1 agonist derived from the MLPCN probe ML071. Bioorganic & Medicinal Chemistry Letters. 21: 6451-5
Lebois EP, Jones CK, Lindsley CW. (2011) The Evolution of Histamine H 3 Antagonists/Inverse Agonists Current Topics in Medicinal Chemistry. 11: 648-660
Lebois EP, Bridges TM, Lewis LM, et al. (2010) Discovery and characterization of novel subtype-selective allosteric agonists for the investigation of M(1) receptor function in the central nervous system. Acs Chemical Neuroscience. 1: 104-121
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