Ryan R. Cupo
Affiliations: | University of Pennsylvania, Philadelphia, PA, United States |
Area:
Proteostasis, Mitochondria, Protein AggregationGoogle:
"Ryan Cupo"Mean distance: (not calculated yet)
Parents
Sign in to add mentor| James H. Eberwine | research assistant | ||
| Gyorgy Hajnoczky | research assistant | Thomas Jefferson | |
| James Shorter | grad student | 2015- | Penn |
| Richard J Youle | post-doc | 2021- | (Chemistry Tree) |
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Publications
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| Mack KL, Kim H, Barbieri EM, et al. (2023) Tuning Hsp104 specificity to selectively detoxify α-synuclein. Molecular Cell |
| Cupo RR, Rizo AN, Braun GA, et al. (2022) Unique structural features govern the activity of a human mitochondrial AAA+ disaggregase, Skd3. Cell Reports. 40: 111408 |
| Warren JT, Cupo RR, Wattanasirakul P, et al. (2021) Heterozygous Variants of CLPB are a Cause of Severe Congenital Neutropenia. Blood |
| Cupo RR, Shorter J. (2020) Expression and Purification of Recombinant Skd3 (Human ClpB) Protein and Tobacco Etch Virus (TEV) Protease from . Bio-Protocol. 10: e3858 |
| Cupo RR, Shorter J. (2020) Skd3 (human ) is a potent mitochondrial protein disaggregase that is inactivated by 3-methylglutaconic aciduria-linked mutations. Elife. 9 |
| Cupo RR, Shorter J. (2020) Author response: Skd3 (human ClpB) is a potent mitochondrial protein disaggregase that is inactivated by 3-methylglutaconic aciduria-linked mutations Elife |
| Cupo RR, Augustine E, Shorter J. (2018) Exploring and Enhancing Compartment-Specific Protein Disaggregases to Combat Neurodegenerative Diseases Biophysical Journal. 114: 578a-579a |
| Lavorato M, Iyer VR, Dewight W, et al. (2017) Increased mitochondrial nanotunneling activity, induced by calcium imbalance, affects intermitochondrial matrix exchanges. Proceedings of the National Academy of Sciences of the United States of America |
| Eisner V, Cupo RR, Gao E, et al. (2017) Mitochondrial fusion dynamics is robust in the heart and depends on calcium oscillations and contractile activity. Proceedings of the National Academy of Sciences of the United States of America |
| Eisner V, Cupo R, Gao E, et al. (2015) Mitochondrial Fusion Dynamics in the Heart Biophysical Journal. 108: 610a |