Lin Guo
Affiliations: | University of Pennsylvania, Philadelphia, PA, United States |
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Parents
Sign in to add mentor| Feng Gai | grad student | Penn (Chemistry Tree) | |
| James Shorter | post-doc | Penn |
Children
Sign in to add trainee| Emma Robinson | research assistant | Thomas Jefferson | |
| Jenny Carey | grad student | Thomas Jefferson | |
| Neha Mohan | grad student | Thomas Jefferson | |
| Amandeep Girdhar | post-doc | Thomas Jefferson |
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Publications
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| Guo L, Mann JR, Mauna JC, et al. (2023) Defining RNA oligonucleotides that reverse deleterious phase transitions of RNA-binding proteins with prion-like domains. Biorxiv : the Preprint Server For Biology |
| Sharma K, Banerjee S, Savran D, et al. (2023) Cryo-EM structure of the full-length hnRNPA1 amyloid fibril. Journal of Molecular Biology. 168211 |
| Gao J, Mewborne QT, Girdhar A, et al. (2022) Poly(ADP-ribose) promotes toxicity of arginine-rich dipeptide repeat proteins. Science Translational Medicine. 14: eabq3215 |
| Girdhar A, Guo L. (2022) Regulating Phase Transition in Neurodegenerative Diseases by Nuclear Import Receptors. Biology. 11 |
| Kim HJ, Mohassel P, Donkervoort S, et al. (2022) Heterozygous frameshift variants in HNRNPA2B1 cause early-onset oculopharyngeal muscular dystrophy. Nature Communications. 13: 2306 |
| Carey JL, Guo L. (2022) Liquid-Liquid Phase Separation of TDP-43 and FUS in Physiology and Pathology of Neurodegenerative Diseases. Frontiers in Molecular Biosciences. 9: 826719 |
| Gottlieb L, Guo L, Shorter J, et al. (2021) N-alpha-acetylation of Huntingtin protein increases its propensity to aggregate. The Journal of Biological Chemistry. 297: 101363 |
| Beijer D, Kim HJ, Guo L, et al. (2021) Characterization of HNRNPA1 mutations defines diversity in pathogenic mechanisms and clinical presentation. Jci Insight. 6 |
| Yoshizawa T, Guo L. (2021) Karyopherin-βs play a key role as a phase separation regulator. Journal of Biochemistry |
| Robinson E, Shorter J, Guo L. (2020) Karyopherin-β2 Inhibits and Reverses Aggregation and Liquid-liquid Phase Separation of the ALS/FTD-Associated Protein FUS. Bio-Protocol. 10: e3725 |