Tasuku Honjo
Affiliations: | 1979-1984 | Genetics | Osaka University Medical School |
1984-2005 | Medical Chemistry | Kyoto University, Kyōto-shi, Kyōto-fu, Japan |
Area:
Molecular ImmunologyWebsite:
https://kuias.kyoto-u.ac.jp/e/profile/honjo/Google:
"Tasuku Honjo"Bio:
The Nobel Prize in Physiology or Medicine 2018 was awarded jointly to James P. Allison and Tasuku Honjo "for their discovery of cancer therapy by inhibition of negative immune regulation"
http://www2.mfour.med.kyoto-u.ac.jp/en/E_CV.html
Mean distance: (not calculated yet)
Cross-listing: ImmunoTree
Parents
Sign in to add mentorOsamu Hayaishi | grad student | 1967-1971 | Kyoto University |
Yasutomi Nishizuka | grad student | 1967-1971 | Kyoto University |
Donald D. Brown | post-doc | 1971-1973 | The Carnegie Institute |
Philip Leder | post-doc | 1973-1974 | NIH |
Children
Sign in to add traineeKoichi Ikuta | grad student | 1983-1987 | Kyoto University (Stem Cell Tree) |
Shigeru Kondo | research scientist | Kyoto University | |
Yasuyoshi Nishida | research scientist |
BETA: Related publications
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Publications
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Akrami M, Menzies R, Chamoto K, et al. (2020) Circulation of gut-preactivated naïve CD8 T cells enhances antitumor immunity in B cell-defective mice. Proceedings of the National Academy of Sciences of the United States of America |
Husain A, Xu J, Fujii H, et al. (2020) SAMHD1-mediated dNTP degradation is required for efficient DNA repair during antibody class switch recombination. The Embo Journal. e102931 |
Islam H, Kobayashi M, Honjo T. (2019) Apurinic/apyrimidinic endonuclease 1 (APE1) is dispensable for activation-induced cytidine deaminase (AID)-dependent somatic hypermutation in the immunoglobulin gene. International Immunology |
Al Ismail A, Husain A, Kobayashi M, et al. (2017) Depletion of recombination specific co-factors by the C-terminal mutant of the activation-induced cytidine deaminase causes the dominant negative effect on class switch recombination. International Immunology |
McDonald G, Medina CO, Pilichowska M, et al. (2017) Accelerated Systemic Autoimmunity in the Absence of Somatic Hypermutation in 564Igi: A Mouse Model of Systemic Lupus with Knocked-In Heavy and Light Chain Genes. Frontiers in Immunology. 8: 1094 |
Zhang B, Chikuma S, Hori S, et al. (2016) Nonoverlapping roles of PD-1 and FoxP3 in maintaining immune tolerance in a novel autoimmune pancreatitis mouse model. Proceedings of the National Academy of Sciences of the United States of America |
Mondal S, Begum NA, Hu W, et al. (2016) Functional requirements of AID's higher order structures and their interaction with RNA-binding proteins. Proceedings of the National Academy of Sciences of the United States of America |
Husain A, Begum NA, Taniguchi T, et al. (2016) Chromatin remodeller SMARCA4 recruits topoisomerase 1 and suppresses transcription-associated genomic instability. Nature Communications. 7: 10549 |
Hu W, Begum NA, Mondal S, et al. (2015) Identification of DNA cleavage- and recombination-specific hnRNP cofactors for activation-induced cytidine deaminase. Proceedings of the National Academy of Sciences of the United States of America. 112: 5791-6 |
Xu J, Husain A, Hu W, et al. (2014) APE1 is dispensable for S-region cleavage but required for its repair in class switch recombination. Proceedings of the National Academy of Sciences of the United States of America. 111: 17242-7 |