Sascha R.A. Alles, Ph.D.

2017- Wolfson Institute for Biomedical Research University College London, London, United Kingdom 
Chronic pain, nociception, ion channels
"Sascha Alles"

I received a BSc Hons in Biochemistry from Imperial College London in 2010, and a PhD in Neuroscience from the University of Alberta in 2016 studying cellular mechanisms of the neuropathic pain drug gabapentin with Prof Peter Smith. I performed postdoctoral work on voltage-gated calcium channels and familial hemiplegic migraine at UBC in the lab of Prof Terry Snutch FRSC and I am currently working on nociceptive pathways at UCL in the lab of Prof John Wood FRS.

My goal is to unravel molecular mechanisms of nociception and chronic pain using a combination of imaging, electrophysiological, bioinformatic and molecular biology techniques. Ultimately, we hope to contribute to the development of more effective therapies for treatment.

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Marco Beato collaborator 2018- UCL
Andrew J. Todd collaborator 2018- University of Glasgow
Ian Winship collaborator 2014-2016 University of Alberta
Glen Baker collaborator 2015-2017 University of Alberta
Brian A. Macvicar collaborator 2016-2017 UBC
Gerald W. Zamponi collaborator 2017-2017 University of Calgary
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Alles SRA, Cain SM, Snutch TP. (2020) Pregabalin as a Pain Therapeutic: Beyond Calcium Channels. Frontiers in Cellular Neuroscience. 14: 83
Alles SRA, Nascimento F, Luján R, et al. (2020) Sensory neuron-derived Na1.7 contributes to dorsal horn neuron excitability. Science Advances. 6: eaax4568
Alles SRA, Smith PA. (2018) Comparison of ex vivo and in vitro actions of gabapentin in superficial dorsal horn and the role of extra-spinal sites of drug action. Neuroscience Letters. 694: 148-153
Bangash MA, Alles SRA, Santana-Varela S, et al. (2018) Distinct transcriptional responses of mouse sensory neurons in models of human chronic pain conditions. Wellcome Open Research. 3: 78
Garcia-Caballero A, Zhang FX, Hodgkinson V, et al. (2018) T-type calcium channels functionally interact with spectrin (α/β) and ankyrin B Molecular Brain
Alles SR, Garcia E, Balasubramanyan S, et al. (2018) Peripheral nerve injury increases contribution of L-type calcium channels to synaptic transmission in spinal lamina II: Role of α2δ-1 subunits. Molecular Pain
Alles SRA, Smith PA. (2018) Etiology and Pharmacology of Neuropathic Pain. Pharmacological Reviews. 70: 315-347
Cain SM, Bohnet B, LeDue J, et al. (2017) In vivo imaging reveals that pregabalin inhibits cortical spreading depression and propagation to subcortical brain structures. Proceedings of the National Academy of Sciences of the United States of America
Alles SR, Bandet MV, Eppler K, et al. (2016) Acute anti-allodynic action of gabapentin in dorsal horn and primary somatosensory cortex: Correlation of behavioural and physiological data. Neuropharmacology
Tolan J, Le QN, Zhang L, et al. (2016) Validation of the ANSR® for Campylobacter Method for Detection of Thermophilic Campylobacter spp. in Chicken Carcass Rinse and Turkey Sponge Samples. Journal of Aoac International
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