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Janet Rossant, Ph.D.

Affiliations: 
Sick Kids 
Area:
Stem cell research, Molecular genetics, Developmental biology
Website:
http://www.sickkids.ca/research/rossant/
Google:
"Janet Rossant"
Bio:

Dr. Janet Rossant is a Senior Scientist in the Developmental & Stem Cell Biology Program and Chief of Research at The Hospital for Sick Children, Toronto. She is also a University Professor, University of Toronto, and Professor in the Departments of Molecular Genetics, Obstetrics/Gynaecology and Paediatrics, University of Toronto. Her research interests centre on understanding the genetic control of normal and abnormal development in the early mouse embryo using both cellular and genetic manipulation techniques. Her interests in the early embryo have led to the discovery of a novel placental stem cell type, the trophoblast stem cell. She is Deputy Scientific Director of the Canadian Stem Cell Network and directs the Centre for Modelling Human Disease in Toronto, which is undertaking genome-wide mutagenesis in mice to develop new mouse models of human disease.

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Mean distance: 17.41 (cluster 57)
 
Cross-listing: DevTree - Chemistry Tree - GenetiTree

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Parents

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Richard L Gardner grad student (Cell Biology Tree)

Children

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Jose La Rose research assistant 1997- Sick Kids (Cell Biology Tree)
Cecilia B. Moens grad student University of Toronto
Cheryle A. Séguin grad student
Brian G. Ciruna grad student 2001 University of Toronto
Tilo J. Kunath grad student 2003 University of Toronto
Robert O. Stephenson grad student 2011 University of Toronto
Ronald Conlon post-doc Sick Kids (DevTree)
Rashmi Kothary post-doc Mount Sinai Hospital (University of Toronto).

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Publications

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Goissis MD, Bradshaw B, Posfai E, et al. (2023) Influence of FGF4 and BMP4 on FGFR2 dynamics during the segregation of epiblast and primitive endoderm cells in the pre-implantation mouse embryo. Plos One. 18: e0279515
Cuevas-Ocaña S, Yang JY, Aushev M, et al. (2023) A Cell-Based Optimised Approach for Rapid and Efficient Gene Editing of Human Pluripotent Stem Cells. International Journal of Molecular Sciences. 24
Pham TXA, Panda A, Kagawa H, et al. (2022) Modeling human extraembryonic mesoderm cells using naive pluripotent stem cells. Cell Stem Cell. 29: 1346-1365.e10
Rossant J, Tam PPL. (2022) Early human embryonic development: Blastocyst formation to gastrulation. Developmental Cell. 57: 152-165
Rossant J, Tam PPL. (2021) Opportunities and Challenges with Stem Cell-Based Embryo Models. Stem Cell Reports
Posfai E, Schell JP, Janiszewski A, et al. (2021) Evaluating totipotency using criteria of increasing stringency. Nature Cell Biology. 23: 49-60
Hyun I, Munsie M, Pera MF, et al. (2020) Toward Guidelines for Research on Human Embryo Models Formed from Stem Cells. Stem Cell Reports
Gu B, Posfai E, Gertsenstein M, et al. (2020) Efficient Generation of Large-Fragment Knock-In Mouse Models Using 2-Cell (2C)-Homologous Recombination (HR)-CRISPR. Current Protocols in Mouse Biology. 10: e67
Okamura E, Tam OH, Posfai E, et al. (2019) Esrrb function is required for proper primordial germ cell development in presomite stage mouse embryos. Developmental Biology
Lee CQ, Bailey A, Lopez-Tello J, et al. (2019) Inhibition of Phosphoinositide-3-kinase signaling promotes the stem cell state of trophoblast. Stem Cells (Dayton, Ohio)
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