Hayk Davtyan, Ph.D.

2017- MIND University of California, Irvine, Irvine, CA 
Alzheimer's disease, Neuroimmunology
"Hayk Davtyan"
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McQuade A, Kang YJ, Hasselmann J, et al. (2020) Gene expression and functional deficits underlie TREM2-knockout microglia responses in human models of Alzheimer's disease. Nature Communications. 11: 5370
Petrushina I, Hovakimyan A, Harahap I, et al. (2020) Characterization and preclinical evaluation of the cGMP grade DNA based vaccine, AV-1959D to enter the first-in-human clinical trials. Neurobiology of Disease. 104823
Davtyan H, Hovakimyan A, Kiani Shabestari S, et al. (2019) Testing a MultiTEP-based combination vaccine to reduce Aβ and tau pathology in Tau22/5xFAD bigenic mice. Alzheimer's Research & Therapy. 11: 107
Hovakimyan A, Antonyan T, Shabestari SK, et al. (2019) A MultiTEP platform-based epitope vaccine targeting the phosphatase activating domain (PAD) of tau: therapeutic efficacy in PS19 mice. Scientific Reports. 9: 15455
Joly-Amado A, Davtyan H, Serraneau K, et al. (2019) Active immunization with tau epitope in a mouse model of tauopathy induced strong antibody response together with improvement in short memory and pSer396-tau pathology. Neurobiology of Disease. 104636
Hasselmann J, Coburn MA, England W, et al. (2019) Development of a Chimeric Model to Study and Manipulate Human Microglia In Vivo. Neuron
Rojo R, Raper A, Ozdemir DD, et al. (2019) Deletion of a Csf1r enhancer selectively impacts CSF1R expression and development of tissue macrophage populations. Nature Communications. 10: 3215
Faal T, Phan DTT, Davtyan H, et al. (2019) Induction of Mesoderm and Neural Crest-Derived Pericytes from Human Pluripotent Stem Cells to Study Blood-Brain Barrier Interactions. Stem Cell Reports
McQuade A, Coburn M, Tu CH, et al. (2018) Development and validation of a simplified method to generate human microglia from pluripotent stem cells. Molecular Neurodegeneration. 13: 67
Davtyan H, Zagorski K, Petrushina I, et al. (2017) MultiTEP platform-based DNA vaccines for alpha-synucleinopathies: preclinical evaluation of immunogenicity and therapeutic potency. Neurobiology of Aging
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