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Michael W. Calik

Affiliations: 
University of Illinois at Chicago, Chicago, IL, United States 
Area:
sleep and breathing
Website:
https://www.nursing.uic.edu/faculty-staff/michael-w-calik-phd
Google:
"Michael W. Calik"
Bio:

The goal of my research career is to investigate pharmacological treatments of sleep-related breathing disorders (e.g. obstructive sleep apnea [OSA]). I am a neuroscientist studying respiratory modulation during sleep.

My published and preliminary results show that dronabinol, a cannabinoid, injected locally into the nodose ganglia (cell bodies of the vagus nerves containing cannabinoid receptors) attenuates reflex apnea and increases upper airway activity in rats; apnea attenuation, but not increases in upper airway activity, is blocked by systemic cannabinoid antagonism. Moreover, systemic administration of dronabinol in chronically instrumented conscious rats decreases apnea index, but also decreases time spent in REM sleep.

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Parents

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Evan B. Stubbs grad student 2005-2011 Loyola University Chicago
David W. Carley post-doc 2012-2015 University of Illinois, Chicago
Miodrag "Misha" Radulovacki post-doc 2012-2015 University of Illinois, Chicago

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Publications

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Calik MW, Carley DW. (2023) DMSO potentiates the suppressive effect of dronabinol on sleep apnea and REM sleep in rats. Journal of Cannabis Research. 5: 30
Petrunich-Rutherford ML, Calik MW. (2021) Effects of Cannabinoid Agonists and Antagonists on Sleep in Laboratory Animals. Advances in Experimental Medicine and Biology. 1297: 97-109
Maki KA, Burke LA, Calik MW, et al. (2020) Sleep fragmentation increases blood pressure and is associated with alterations in the gut microbiome and fecal metabolome in rats. Physiological Genomics
Fink AM, Bronas UG, Calik MW. (2018) Autonomic regulation during sleep and wakefulness: a review with implications for defining the pathophysiology of neurological disorders. Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society
Calik MW, Carley DW. (2017) Effects of Cannabinoid Agonists and Antagonists on Sleep and Breathing in Sprague-Dawley Rats. Sleep. 40
Calik M, Carley D. (2017) 0140 CO-LOCALIZATION OF SEROTONIN AND CANNABINOID RECEPTORS IN THE NODOSE GANGLIA Sleep. 40: A52-A52
Calik MW, Carley DW. (2016) Intracerebroventricular injections of dronabinol, a cannabinoid receptor agonist, does not attenuate serotonin-induced apnea in Sprague-Dawley rats. Journal of Negative Results in Biomedicine. 15: 8
Calik MW, Shankarappa SA, Langert KA, et al. (2015) Forced Exercise Preconditioning Attenuates Experimental Autoimmune Neuritis by Altering Th1 Lymphocyte Composition and Egress. Asn Neuro. 7
Calik MW, Radulovacki M, Carley DW. (2014) A method of nodose ganglia injection in Sprague-Dawley rat. Journal of Visualized Experiments : Jove. e52233
Weaver TE, Calik MW, Farabi SS, et al. (2014) Innovative treatments for adults with obstructive sleep apnea. Nature and Science of Sleep. 6: 137-47
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