Todd Macklin, Ph.D.
Affiliations: | Chemistry | Takeda Pharmaceuticals, Deerfield, IL, United States |
Website:
http://www.linkedin.com/pub/todd-macklin-ph-d/17/16a/3bGoogle:
"Todd Macklin"Mean distance: 8.28 | S | N | B | C | P |
Parents
Sign in to add mentor| Victor A. Snieckus | grad student | 2007 | Queens University |
| Glenn Christopher Micalizio | post-doc | 2007-2010 | Scripps Research Institute Florida |
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Publications
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| Sun H, Monenschein H, Schiffer HH, et al. (2021) First-Time Disclosure of CVN424, a Potent and Selective GPR6 Inverse Agonist for the Treatment of Parkinson's Disease: Discovery, Pharmacological Validation, and Identification of a Clinical Candidate. Journal of Medicinal Chemistry |
| Jeso V, Cherry L, Macklin TK, et al. (2011) Convergent synthesis and discovery of a natural product-inspired paralog-selective Hsp90 inhibitor. Organic Letters. 13: 5108-11 |
| Macklin TK, Micalizio GC. (2010) Convergent and stereospecific synthesis of complex skipped polyenes and polyunsaturated fatty acids. Nature Chemistry. 2: 638-43 |
| Hurst TE, Macklin TK, Becker M, et al. (2010) Iridium-catalyzed C-H activation versus directed ortho metalation: complementary borylation of aromatics and heteroaromatics. Chemistry (Weinheim An Der Bergstrasse, Germany). 16: 8155-61 |
| Macklin TK, Micalizio GC. (2009) Total synthesis and structure elucidation of (+)-phorbasin C. Journal of the American Chemical Society. 131: 1392-3 |
| Macklin TK, Panteleev J, Snieckus V. (2008) Carbamoyl translocations by an anionic ortho-fries and cumulenolate alpha-acylation pathway: regioselective synthesis of polysubstituted chromone 3- and 8-carboxamides. Angewandte Chemie (International Ed. in English). 47: 2097-101 |
| Macklin TK, Reed MA, Snieckus V. (2008) Combined metalation-cross coupling strategies: A synthesis of schumanniophytine by a key biaryl O-carbamate remote anionic fries rearrangement European Journal of Organic Chemistry. 1507-1509 |
| Blanchet J, Macklin T, Ang P, et al. (2007) Directed ortho metalation-cross coupling strategies. N-cumyl arylsulfonamides. Facile deprotection and expedient route to 7- and 4,7-substituted saccharins. The Journal of Organic Chemistry. 72: 3199-206 |
| Macklin TK, Snieckus V. (2005) Directed ortho metalation methodology. The N,N-dialkyl aryl O-sulfamate as a new directed metalation group and cross-coupling partner for Grignard reagents. Organic Letters. 7: 2519-22 |