Venkatraman Junnotula, Ph.D.
Affiliations: | 2008 | Chemistry | University of Missouri - Columbia, Columbia, MO, United States |
Area:
Organic Chemistry, Pharmaceutical ChemistryGoogle:
"Venkatraman Junnotula"Mean distance: (not calculated yet)
Parents
Sign in to add mentor| Kent S. Gates | grad student | 2008 | University of Missouri - Columbia | |
| (Chemical mechanisms underlying the medicinal activity of metabolically-activated N-oxide antitumor agents.) | ||||
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Publications
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| Perez HL, Junnotula V, Knecht D, et al. (2014) Analytical approaches for quantification of a Nrf2 pathway activator: overcoming bioanalytical challenges to support a toxicity study. The Analyst. 139: 1902-12 |
| Shen X, Rajapakse A, Gallazzi F, et al. (2014) Isotopic labeling experiments that elucidate the mechanism of DNA strand cleavage by the hypoxia-selective antitumor agent 1,2,4-benzotriazine 1,4-di-N-oxide. Chemical Research in Toxicology. 27: 111-8 |
| Junnotula V, Rajapakse A, Arbillaga L, et al. (2010) DNA strand cleaving properties and hypoxia-selective cytotoxicity of 7-chloro-2-thienylcarbonyl-3-trifluoromethylquinoxaline 1,4-dioxide. Bioorganic & Medicinal Chemistry. 18: 3125-32 |
| Junnotula V, Sarkar U, Sinha S, et al. (2009) Initiation of DNA strand cleavage by 1,2,4-benzotriazine 1,4-dioxide antitumor agents: mechanistic insight from studies of 3-methyl-1,2,4-benzotriazine 1,4-dioxide. Journal of the American Chemical Society. 131: 1015-24 |
| Solano B, Junnotula V, Marín A, et al. (2007) Synthesis and biological evaluation of new 2-arylcarbonyl-3-trifluoromethylquinoxaline 1,4-di-N-oxide derivatives and their reduced analogues. Journal of Medicinal Chemistry. 50: 5485-92 |
| Chowdhury G, Junnotula V, Daniels JS, et al. (2007) DNA strand damage product analysis provides evidence that the tumor cell-specific cytotoxin tirapazamine produces hydroxyl radical and acts as a surrogate for O(2). Journal of the American Chemical Society. 129: 12870-7 |
| Junnotula V, Sarkar U, Barnes CL, et al. (2006) Crystal structures of 3-methyl-1,2,4-benzotriazine 1-oxide and 2-oxide Journal of Chemical Crystallography. 36: 557-561 |