S. Michael Owens

Affiliations: 
Pharmacology and Toxicology University of Arkansas for Medical Sciences, United States 
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Children

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Kelly A. Byrnes-Blake grad student 2001 UAMS
Alessandra Milesi-Halle grad student 2005 UAMS
Jonathan J. Hubbard grad student 2008 UAMS
Michael D. Hambuchen grad student 2013 UAMS

Collaborators

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William E. Fantegrossi collaborator 2015- UAMS
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Publications

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Hambuchen MD, Hendrickson HP, Owens SM. (2017) Chiral determination of 3,4-methylenedioxypyrovalerone enantiomers in rat serum. Analytical Methods : Advancing Methods and Applications. 9: 609-617
Owens SM, Pollard GT, Howard JL, et al. (2016) Pharmacodynamic Relationships between Duration of Action of JDTic-like Kappa-Opioid Receptor Antagonists and Their Brain and Plasma Pharmacokinetics in Rats. Acs Chemical Neuroscience
Reichard EE, Nanaware-Kharade N, Gonzalez GA, et al. (2016) PEGylation of a High-Affinity Anti-(+)Methamphetamine Single Chain Antibody Fragment Extends Functional Half-Life by Reducing Clearance. Pharmaceutical Research
Hambuchen MD, Rüedi-Bettschen D, Gunnell MG, et al. (2016) Chronic Treatment of (+)-Methamphetamine-Induced Locomotor Effects in Rats Using One or a Combination of Two High Affinity Anti-Methamphetamine Monoclonal Antibodies. Human Vaccines & Immunotherapeutics. 0
Stevens MW, Gunnell MG, Tawney R, et al. (2016) Optimization of a methamphetamine conjugate vaccine for antibody production in mice. International Immunopharmacology. 35: 137-141
Hambuchen MD, Carroll FI, Rüedi-Bettschen D, et al. (2015) Combining Active Immunization with Monoclonal Antibody Therapy To Facilitate Early Initiation of a Long-Acting Anti-Methamphetamine Antibody Response. Journal of Medicinal Chemistry. 58: 4665-77
Stevens MW, Henry RL, Owens SM, et al. (2014) First human study of a chimeric anti-methamphetamine monoclonal antibody in healthy volunteers. Mabs. 6: 1649-56
Laurenzana EM, Stevens MW, Frank JC, et al. (2014) Pharmacological effects of two anti-methamphetamine monoclonal antibodies. Supporting data for lead candidate selection for clinical development. Human Vaccines & Immunotherapeutics. 10: 2638-47
Peterson EC, Hambuchen MD, Tawney RL, et al. (2014) Simple radiometric method for accurately quantitating epitope densities of hapten-protein conjugates with sulfhydryl linkages. Bioconjugate Chemistry. 25: 2112-5
Hambuchen MD, Rüedi-Bettschen D, Williams DK, et al. (2014) Treatment of rats with an anti-(+)-methamphetamine monoclonal antibody shortens the duration of action of repeated (+)-methamphetamine challenges over a one month period. Vaccine. 32: 6213-9
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