Gaynor A Smith

Affiliations: 
Cardiff University, Cardiff, Wales, United Kingdom 
Area:
Drosophila, Parkinson's disease, Huntington's disease, mitochondria
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Parents

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Stephen B. Dunnett grad student 2007-2020
Ole Isacson post-doc 2011-2014
Marc R. Freeman post-doc 2014-2017
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Publications

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Lin TH, Bis-Brewer DM, Sheehan AE, et al. (2021) TSG101 negatively regulates mitochondrial biogenesis in axons. Proceedings of the National Academy of Sciences of the United States of America. 118
Peters OM, Weiss A, Metterville J, et al. (2021) Genetic diversity of axon degenerative mechanisms in models of Parkinson's disease. Neurobiology of Disease. 105368
Precious SV, Smith GA, Heuer A, et al. (2020) Dopaminergic Progenitors Derived From Epiblast Stem Cells Function Similarly to Primary VM-Derived Progenitors When Transplanted Into a Parkinson's Disease Model. Frontiers in Neuroscience. 14: 312
Malik BR, Maddison DC, Smith GA, et al. (2019) Autophagic and endo-lysosomal dysfunction in neurodegenerative disease. Molecular Brain. 12: 100
Smith GA, Lin TH, Sheehan AE, et al. (2019) Glutathione S-Transferase Regulates Mitochondrial Populations in Axons through Increased Glutathione Oxidation. Neuron
Breger LS, Kienle K, Smith GA, et al. (2016) Influence of chronic L-DOPA treatment on immune response following allogeneic and xenogeneic graft in a rat model of Parkinson's disease. Brain, Behavior, and Immunity
Smith GA, Jansson J, Rocha EM, et al. (2015) Fibroblast Biomarkers of Sporadic Parkinson's Disease and LRRK2 Kinase Inhibition. Molecular Neurobiology
Rocha EM, Smith GA, Park E, et al. (2015) Glucocerebrosidase gene therapy prevents α-synucleinopathy of midbrain dopamine neurons. Neurobiology of Disease
Lewis EA, Smith GA. (2015) Using Drosophila models of Huntington's disease as a translatable tool. Journal of Neuroscience Methods
Rocha EM, Smith GA, Park E, et al. (2015) Chronic pharmacological glucocerebrosidase inhibition induces α-synuclein aggregation, microglial and complement activation and synaptic protein changes in mice. Antioxidants & Redox Signaling
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