Gaynor A Smith

Cardiff University, Cardiff, Wales, United Kingdom 
Drosophila, Parkinson's disease, Huntington's disease, mitochondria
"Gaynor Smith"
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Stephen B. Dunnett grad student 2007-2020
Ole Isacson post-doc 2011-2014
Marc R. Freeman post-doc 2014-2017
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Breger LS, Kienle K, Smith GA, et al. (2016) Influence of chronic L-DOPA treatment on immune response following allogeneic and xenogeneic graft in a rat model of Parkinson's disease. Brain, Behavior, and Immunity
Rocha EM, Smith GA, Park E, et al. (2015) Glucocerebrosidase gene therapy prevents α-synucleinopathy of midbrain dopamine neurons. Neurobiology of Disease
Rocha EM, Smith GA, Park E, et al. (2015) Chronic pharmacological glucocerebrosidase inhibition induces α-synuclein aggregation, microglial and complement activation and synaptic protein changes in mice. Antioxidants & Redox Signaling
Rocha EM, Smith GA, Park E, et al. (2015) Progressive decline of glucocerebrosidase in aging and Parkinson's disease. Annals of Clinical and Translational Neurology. 2: 433-8
Smith GA, Rocha EM, Rooney T, et al. (2015) A Nurr1 agonist causes neuroprotection in a Parkinson's disease lesion model primed with the toll-like receptor 3 dsRNA inflammatory stimulant poly(I:C). Plos One. 10: e0121072
Hallett PJ, Deleidi M, Astradsson A, et al. (2015) Successful function of autologous iPSC-derived dopamine neurons following transplantation in a non-human primate model of Parkinson's disease. Cell Stem Cell. 16: 269-74
McLean JR, Smith GA, Rocha EM, et al. (2014) ALS-associated peripherin spliced transcripts form distinct protein inclusions that are neuroprotective against oxidative stress. Experimental Neurology. 261: 217-29
McLean JR, Smith GA, Rocha EM, et al. (2014) Widespread neuron-specific transgene expression in brain and spinal cord following synapsin promoter-driven AAV9 neonatal intracerebroventricular injection. Neuroscience Letters. 576: 73-8
Smith GA, Rocha EM, McLean JR, et al. (2014) Progressive axonal transport and synaptic protein changes correlate with behavioral and neuropathological abnormalities in the heterozygous Q175 KI mouse model of Huntington's disease. Human Molecular Genetics. 23: 4510-27
Smith GA, Snyder EY. (2013) Two cells are better than one: optimizing stem cell survival by co-grafting "helper" cells that offer regulated trophic support. Experimental Neurology. 247: 751-4
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