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Santosh K. Keshipeddy, Ph.D.

Affiliations: 
2012 University of Connecticut, Storrs, CT, United States 
Area:
Organic Chemistry
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Amy Ruth Howell grad student 2012 University of Connecticut
 (Synthesis of carbohydrate modified alpha-galactosylceramide analogs and the discovery of novel reactions involving strained heterocycles.)

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Publications

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Saavedra-Avila NA, Keshipeddy S, Guberman-Pfeffer MJ, et al. (2020) Amide-Linked C4″-Saccharide Modification of KRN7000 Provides Potent Stimulation of Human Invariant NKT Cells and Anti-Tumor Immunity in a Humanized Mouse Model. Acs Chemical Biology
Cannone Z, Shaqra A, Lorenc C, et al. (2019) Post Glycosylation Diversification (PGD): An Approach for Assembling Collections of Glycosylated Small Molecules. Acs Combinatorial Science
Chennamadhavuni D, Saavedra-Avila NA, Carreño LJ, et al. (2018) Dual Modifications of α-Galactosylceramide Synergize to Promote Activation of Human Invariant Natural Killer T Cells and Stimulate Anti-tumor Immunity. Cell Chemical Biology. 25: 925
Chennamadhavuni D, Saavedra-Avila NA, Carreño LJ, et al. (2018) Dual Modifications of α-Galactosylceramide Synergize to Promote Activation of Human Invariant Natural Killer T Cells and Stimulate Anti-tumor Immunity. Cell Chemical Biology
Li S, Diego-Limpin PA, Bajrami B, et al. (2017) Scaling Proteome-wide Reactions of Activity-Based Probes. Analytical Chemistry
Le Nours J, Praveena T, Pellicci DG, et al. (2016) Atypical natural killer T-cell receptor recognition of CD1d-lipid antigens. Nature Communications. 7: 10570
Farber E, Rudnitskaya A, Keshipeddy S, et al. (2013) Silicon acceleration of a tandem alkene isomerization/electrocyclic ring-opening of 2-methyleneoxetanes to α,β-unsaturated methylketones. The Journal of Organic Chemistry. 78: 11213-20
Wun KS, Ross F, Patel O, et al. (2012) Human and mouse type I natural killer T cell antigen receptors exhibit different fine specificities for CD1d-antigen complex. The Journal of Biological Chemistry. 287: 39139-48
Keshipeddy S, Martínez I, Castillo BF, et al. (2012) Toward a formal synthesis of laureatin: unexpected rearrangements involving cyclic ether nucleophiles. The Journal of Organic Chemistry. 77: 7883-90
Wun KS, Cameron G, Patel O, et al. (2011) A molecular basis for the exquisite CD1d-restricted antigen specificity and functional responses of natural killer T cells. Immunity. 34: 327-39
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