Gunnar Schulte
Affiliations: | 2002-2005 | MBB | Karolinska Institute, Stockholm, Sweden |
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Parents
Sign in to add mentor| Bertil B. Fredholm | grad student | Karolinska | |
| Ernest Arenas | post-doc | 2002-2005 | Karolinska |
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Publications
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| Grätz L, Kowalski-Jahn M, Scharf MM, et al. (2023) Pathway selectivity in Frizzleds is achieved by conserved micro-switches defining pathway-determining, active conformations. Nature Communications. 14: 4573 |
| Grätz L, Sajkowska-Kozielewicz JJ, Wesslowski J, et al. (2023) NanoBiT- and NanoBiT/BRET-based assays allow the analysis of binding kinetics of Wnt-3a to endogenous Frizzled 7 in a colorectal cancer model. British Journal of Pharmacology |
| Bowin CF, Kozielewicz P, Grätz L, et al. (2023) WNT stimulation induces dynamic conformational changes in the Frizzled-Dishevelled interaction. Science Signaling. 16: eabo4974 |
| Schihada H, Klompstra TM, Humphrys LJ, et al. (2022) Isoforms of GPR35 have distinct extracellular N-termini that allosterically modify receptor-transducer coupling and mediate intracellular pathway bias. The Journal of Biological Chemistry. 102328 |
| Kozielewicz P, Schihada H, Schulte G. (2021) Employing Genetically Encoded, Biophysical Sensors to Understand WNT/Frizzled Interaction and Receptor Complex Activation. Handbook of Experimental Pharmacology |
| Kozielewicz P, Shekhani R, Moser S, et al. (2021) Quantitative Profiling of WNT-3A Binding to All Human Frizzled Paralogues in HEK293 Cells by NanoBiT/BRET Assessments. Acs Pharmacology & Translational Science. 4: 1235-1245 |
| Schihada H, Kowalski-Jahn M, Turku A, et al. (2020) Deconvolution of WNT-induced Frizzled conformational dynamics with fluorescent biosensors. Biosensors & Bioelectronics. 177: 112948 |
| Schihada H, Ma X, Zabel U, et al. (2020) Development of a conformational histamine H receptor biosensor for the synchronous screening of agonists and inverse agonists. Acs Sensors |
| Wesslowski J, Kozielewicz P, Wang X, et al. (2020) eGFP-tagged Wnt-3a enables functional analysis of Wnt trafficking and signaling and kinetic assessment of Wnt binding to full-length Frizzled. The Journal of Biological Chemistry |
| Kozielewicz P, Turku A, Bowin CF, et al. (2020) Structural insight into small molecule action on Frizzleds. Nature Communications. 11: 414 |