Steven G Grinnell

Columbia University, New York, NY 
Opioid pharmacology, addiction, depression
"Steven Grinnell"
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Kruegel AC, Uprety R, Grinnell SG, et al. (2019) 7-Hydroxymitragynine Is an Active Metabolite of Mitragynine and a Key Mediator of Its Analgesic Effects. Acs Central Science. 5: 992-1001
Samuels BA, Nautiyal KM, Kruegel AC, et al. (2017) The Behavioral Effects of the Antidepressant Tianeptine Require the Mu Opioid Receptor. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology
Váradi A, Marrone GF, Palmer TC, et al. (2016) Mitragynine/corynantheidine pseudoindoxyls as opioid analgesics with mu agonism and delta antagonism which do not recruit β-arrestin-2. Journal of Medicinal Chemistry
Grinnell SG, Ansonoff M, Marrone GF, et al. (2016) Mediation of buprenorphine analgesia by a combination of traditional and truncated mu opioid receptor splice variants. Synapse (New York, N.Y.)
Marrone GF, Grinnell SG, Lu Z, et al. (2016) Truncated mu opioid GPCR variant involvement in opioid-dependent and opioid-independent pain modulatory systems within the CNS. Proceedings of the National Academy of Sciences of the United States of America
Pickett JE, Váradi A, Palmer TC, et al. (2015) Mild, Pd-catalyzed stannylation of radioiodination targets. Bioorganic & Medicinal Chemistry Letters. 25: 1761-4
Grinnell SG, Majumdar S, Narayan A, et al. (2014) Pharmacologic characterization in the rat of a potent analgesic lacking respiratory depression, IBNtxA. The Journal of Pharmacology and Experimental Therapeutics. 350: 710-8
Váradi A, Hosztafi S, Le Rouzic V, et al. (2013) Novel 6β-acylaminomorphinans with analgesic activity. European Journal of Medicinal Chemistry. 69: 786-9
Pickett JE, Nagakura K, Pasternak AR, et al. (2013) Sandmeyer reaction repurposed for the site-selective, non-oxidizing radioiodination of fully-deprotected peptides: studies on the endogenous opioid peptide α-neoendorphin. Bioorganic & Medicinal Chemistry Letters. 23: 4347-50
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