Lei Shi, Ph.D
Affiliations: | 2015- | Molecular & Behavioral Neuroscience Institute (MBNI) | University of Michigan, Ann Arbor, Ann Arbor, MI |
Area:
Human brain evolution and developmentWebsite:
https://scholar.google.com/citations?hl=en&user=NQGJ_DEAAAAJGoogle:
"Lei Shi"Bio:
Before coming to USA, I was grown up in the population genetics and molecular evolution lab in China. My previous research focuses on human brain evolution and genetics by studying microcephaly genes especially MCPH1 evolution and function in order to explore our intelligence origin of human species. I am now a postdoc research fellow of University of Michigan Ann Arbor since July 2015 to study mouse brain development in the Kenneth Y.Kwan lab.
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Publications
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| Cao C, Han P, Liu L, et al. (2021) Epithelial Cell Transforming Factor ECT2 Is an Important Regulator of DNA Double-Strand Break Repair and Genome Stability. The Journal of Biological Chemistry. 101036 |
| Keil JM, Doyle DZ, Qalieh A, et al. (2020) Symmetric neural progenitor divisions require chromatin-mediated homologous recombination DNA repair by Ino80. Nature Communications. 11: 3839 |
| Shi L, Qalieh A, Lam MM, et al. (2019) Robust elimination of genome-damaged cells safeguards against brain somatic aneuploidy following Knl1 deletion. Nature Communications. 10: 2588 |
| Mendizabal I, Shi L, Keller TE, et al. (2016) Comparative Methylome Analyses Identify Epigenetic Regulatory Loci of Human Brain Evolution. Molecular Biology and Evolution |
| Khurana S, Kruhlak MJ, Kim J, et al. (2014) A macrohistone variant links dynamic chromatin compaction to BRCA1-dependent genome maintenance. Cell Reports. 8: 1049-62 |
| Li X, Liu L, Yang S, et al. (2014) Histone demethylase KDM5B is a key regulator of genome stability. Proceedings of the National Academy of Sciences of the United States of America. 111: 7096-101 |
| Shi L, Li M, Su B. (2012) MCPH1/BRIT1 represses transcription of the human telomerase reverse transcriptase gene Gene. 495: 1-9 |
| Shi L, Su B. (2012) Identification and functional characterization of a primate-specific E2F1 binding motif regulating MCPH1 expression. Febs Journal. 279: 491-503 |