Toshiyuki Shimizu
Affiliations: | Tokyo University, Minato-ku, Tōkyō-to, Japan |
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| Ishizaka ST, Hawkins L, Chen Q, et al. (2023) A novel Toll-like receptor 7/8-specific antagonist E6742 Ameliorates clinically relevant disease parameters in murine models of lupus. European Journal of Pharmacology. 175962 |
| Shibata T, Sato R, Taoka M, et al. (2023) TLR7/8 stress response drives histiocytosis in SLC29A3 disorders. The Journal of Experimental Medicine. 220 |
| Sakaniwa K, Fujimura A, Shibata T, et al. (2023) TLR3 forms a laterally aligned multimeric complex along double-stranded RNA for efficient signal transduction. Nature Communications. 14: 164 |
| Asami J, Shimizu T. (2021) Structural and functional understanding of the Toll-like receptors. Protein Science : a Publication of the Protein Society |
| Ishida H, Asami J, Zhang Z, et al. (2021) Cryo-EM structures of Toll-like receptors in complex with UNC93B1. Nature Structural & Molecular Biology |
| Tojo S, Zhang Z, Matsui H, et al. (2020) Structural analysis reveals TLR7 dynamics underlying antagonism. Nature Communications. 11: 5204 |
| Sakaniwa K, Shimizu T. (2020) Targeting the innate immune receptor TLR8 using small-molecule agents. Corrigendum. Acta Crystallographica. Section D, Structural Biology. 76: 905-907 |
| Sakaniwa K, Shimizu T. (2020) Targeting the innate immune receptor TLR8 using small-molecule agents. Acta Crystallographica. Section D, Structural Biology. 76: 621-629 |
| Kanoh H, Nitta T, Go S, et al. (2020) Homeostatic and pathogenic roles of GM3 ganglioside molecular species in TLR4 signaling in obesity. The Embo Journal. e101732 |
| Jiang S, Tanji H, Yin K, et al. (2020) Rationally designed small-molecule inhibitors targeting an unconventional pocket on the TLR8 protein-protein interface. Journal of Medicinal Chemistry |