Alexander M. Holtz

Affiliations: 
Cell and Developmental Biology University of Michigan, Ann Arbor, Ann Arbor, MI 
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Holtz AM, Griffiths SC, Davis SJ, et al. (2015) Secreted HHIP1 interacts with heparan sulfate and regulates Hedgehog ligand localization and function. The Journal of Cell Biology. 209: 739-58
Song JY, Holtz AM, Pinskey JM, et al. (2015) Distinct structural requirements for CDON and BOC in the promotion of Hedgehog signaling. Developmental Biology. 402: 239-52
Mathew E, Zhang Y, Holtz AM, et al. (2015) Abstract A51: Novel Hedgehog co-receptors in pancreatic cancer Cancer Research. 75
Mathew E, Zhang Y, Holtz AM, et al. (2014) Dosage-dependent regulation of pancreatic cancer growth and angiogenesis by hedgehog signaling. Cell Reports. 9: 484-94
Camp D, Haitian He B, Li S, et al. (2014) Ihog and Boi elicit Hh signaling via Ptc but do not aid Ptc in sequestering the Hh ligand. Development (Cambridge, England). 141: 3879-88
Mathew E, Collins MA, Fernandez-Barrena MG, et al. (2014) The transcription factor GLI1 modulates the inflammatory response during pancreatic tissue remodeling. The Journal of Biological Chemistry. 289: 27727-43
Holtz AM, Peterson KA, Nishi Y, et al. (2013) Essential role for ligand-dependent feedback antagonism of vertebrate hedgehog signaling by PTCH1, PTCH2 and HHIP1 during neural patterning. Development (Cambridge, England). 140: 3423-34
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