kun ping lu
Affiliations: | Medicine | Harvard Medical School, Boston, MA, United States |
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| Lu KP, Zhou XZ. (2024) Pin1-catalyzed conformational regulation after phosphorylation: A distinct checkpoint in cell signaling and drug discovery. Science Signaling. 17: eadi8743 |
| Jeong J, Usman M, Li Y, et al. (2024) Pin1-Catalyzed Conformation Changes Regulate Protein Ubiquitination and Degradation. Cells. 13 |
| Ke S, Dang F, Wang L, et al. (2024) Reciprocal antagonism of PIN1-APC/C governs mitotic protein stability and cell cycle entry. Nature Communications. 15: 3220 |
| Wang R, Lu KP, Zhou XZ. (2023) Function and regulation of cis P-tau in the pathogenesis and treatment of conventional and nonconventional tauopathies. Journal of Neurochemistry |
| Qiu C, Albayram O, Kondo A, et al. (2021) Cis P-tau underlies vascular contribution to cognitive impairment and dementia and can be effectively targeted by immunotherapy in mice. Science Translational Medicine. 13 |
| Pinch BJ, Doctor ZM, Nabet B, et al. (2020) Identification of a potent and selective covalent Pin1 inhibitor. Nature Chemical Biology |
| Chen D, Mei Y, Kim N, et al. (2020) Melatonin Directly Binds and Inhibits Death-Associated Protein Kinase 1 Function in Alzheimer's Disease. Journal of Pineal Research. e12665 |
| Luo ML, Zheng F, Chen W, et al. (2020) Inactivation of the prolyl isomerase Pin1 sensitizes BRCA1-proficient breast cancer to PARP inhibition. Cancer Research |
| Albayram O, MacIver B, Mathai J, et al. (2019) Traumatic Brain Injury-related voiding dysfunction in mice is caused by damage to rostral pathways, altering inputs to the reflex pathways. Scientific Reports. 9: 8646 |
| Chen L, Xu X, Wen X, et al. (2019) Targeting PIN1 exerts potent antitumor activity in pancreatic ductal carcinoma via inhibiting tumor metastasis. Cancer Science |