Ashley E. Frakes

Ohio State University, Columbus, Columbus, OH 
ALS, microglia
"Ashley Frakes"
Mean distance: 22.43 (cluster 19)


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Brian K. Kaspar grad student Ohio State
Andrew Dillin post-doc UC Berkeley (Cell Biology Tree)
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Bar-Ziv R, Frakes AE, Higuchi-Sanabria R, et al. (2020) Measurements of Physiological Stress Responses in C. Elegans. Journal of Visualized Experiments : Jove
Frakes AE, Metcalf MG, Tronnes SU, et al. (2020) Four glial cells regulate ER stress resistance and longevity via neuropeptide signaling in . Science (New York, N.Y.). 367: 436-440
Frakes AE, Dillin A. (2017) The UPR(ER): Sensor and Coordinator of Organismal Homeostasis. Molecular Cell. 66: 761-771
Frakes AE, Braun L, Ferraiuolo L, et al. (2017) Additive amelioration of ALS by co-targeting independent pathogenic mechanisms. Annals of Clinical and Translational Neurology. 4: 76-86
Ahmed SS, Schattgen SA, Frakes AE, et al. (2016) rAAV gene therapy in a Canavan's disease mouse model reveals immune impairments and an extended pathology beyond the central nervous system. Molecular Therapy : the Journal of the American Society of Gene Therapy
Song S, Miranda CJ, Braun L, et al. (2016) Major histocompatibility complex class I molecules protect motor neurons from astrocyte-induced toxicity in amyotrophic lateral sclerosis. Nature Medicine
Gu JM, Wang DJ, Peterson JM, et al. (2016) An NF-κB - EphrinA5-Dependent Communication between NG2(+) Interstitial Cells and Myoblasts Promotes Muscle Growth in Neonates. Developmental Cell
Frakes AE, Ferraiuolo L, Haidet-Phillips AM, et al. (2014) Microglia induce motor neuron death via the classical NF-κB pathway in amyotrophic lateral sclerosis. Neuron. 81: 1009-23
Ferraiuolo L, Frakes A, Kaspar BK. (2013) Neural stem cells as a therapeutic approach for amyotrophic lateral sclerosis. Molecular Therapy : the Journal of the American Society of Gene Therapy. 21: 503-5
Fidler JA, Treleaven CM, Frakes A, et al. (2011) Disease progression in a mouse model of amyotrophic lateral sclerosis: the influence of chronic stress and corticosterone. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 25: 4369-77
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