Nicholas M Kanaan

Affiliations: 
Michigan State University, East Lansing, MI 
Area:
Alzheimer's Disease, dementia, tauoapthies, tau protein, cytoskeleton, transport, neurodegeneration
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"Nicholas Kanaan"
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Parents

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Gary L. Dunbar research assistant 1998-2001 Central Michigan University
 (Undergraduate Research Assistant)
Timothy  J. Collier grad student 2001-2007 Rush University Medical Center
Lester I. Binder post-doc 2007-2010 Northwestern

Children

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Rebecca Dangremond grad student 2018- Michigan State
Andrew Kneynsberg grad student 2012-2018 Michigan State
Kyle R Christensen grad student 2020-2018 Michigan State
Kristine K Donis-Cox post-doc 2013-2015 Michigan State
Benjamin N. Combs post-doc 2012-2017 Michigan State (Chemistry Tree)
Chelsea T. Tiernan post-doc 2013-2017 Michigan State
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Publications

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Yamaguchi T, Hamano T, Sada K, et al. (2024) Syk inhibitors reduce tau protein phosphorylation and oligomerization. Neurobiology of Disease. 106656
Beckman D, Diniz GB, Ott S, et al. (2024) Temporal progression of tau pathology and neuroinflammation in a rhesus monkey model of Alzheimer's disease. Alzheimer's & Dementia : the Journal of the Alzheimer's Association
Alhadidy MM, Kanaan NM. (2024) Biochemical approaches to assess the impact of post-translational modifications on pathogenic tau conformations using recombinant protein. Biochemical Society Transactions. 52: 301-318
Mueller RL, Kanaan NM, Combs B. (2023) Using Live-Cell Imaging to Measure the Effects of Pathological Proteins on Axonal Transport in Primary Hippocampal Neurons. Journal of Visualized Experiments : Jove
Kanaan NM. (2023) Tau here, tau there, tau almost everywhere: Clarifying the distribution of tau in the adult CNS. Cytoskeleton (Hoboken, N.J.)
Benskey MJ, Panoushek S, Saito T, et al. (2023) Behavioral and neuropathological characterization over the adult lifespan of the human tau knock-in mouse. Frontiers in Aging Neuroscience. 15: 1265151
Samelson AJ, Ariqat N, McKetney J, et al. (2023) CRISPR screens in iPSC-derived neurons reveal principles of tau proteostasis. Biorxiv : the Preprint Server For Biology
Christensen KR, Combs B, Richards C, et al. (2023) Phosphomimetics at Ser199/Ser202/Thr205 in Tau Impairs Axonal Transport in Rat Hippocampal Neurons. Molecular Neurobiology
Ono M, Komatsu M, Ji B, et al. (2022) Central role for p62/SQSTM1 in the elimination of toxic tau species in a mouse model of tauopathy. Aging Cell. e13615
Lin G, Zhu F, Kanaan NM, et al. (2021) Clioquinol Decreases Levels of Phosphorylated, Truncated, and Oligomerized Tau Protein. International Journal of Molecular Sciences. 22
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