Darrell J Irvine

Affiliations: 
Department of Biological Engineering Massachusetts Institute of Technology, Cambridge, MA, United States 
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"Darrell Irvine"
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Parents

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Linda Griffith grad student 2002 MIT (Chemistry Tree)

Children

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Simon J Liang grad student 2019-2021 MIT (Chemistry Tree)
B.J. Byungji Kim post-doc 2019- MIT
Christopher M. Jewell post-doc 2009-2012 MIT (Chemistry Tree)
Gregory L. Szeto post-doc 2011-2015 MIT (Microtree)
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Publications

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Bhagchandani SH, Yang L, Maiorino L, et al. (2023) Two-dose "extended priming" immunization amplifies humoral immune responses by synchronizing vaccine delivery with the germinal center response. Biorxiv : the Preprint Server For Biology
Bergaggio E, Tai WT, Aroldi A, et al. (2023) ALK inhibitors increase ALK expression and sensitize neuroblastoma cells to ALK.CAR-T cells. Cancer Cell
Phung I, Rodrigues KA, Marina-Zárate E, et al. (2023) A combined adjuvant approach primes robust germinal center responses and humoral immunity in non-human primates. Nature Communications. 14: 7107
Mandal S, Melo M, Gordiichuk P, et al. (2023) WASP facilitates tumor mechanosensitivity in T lymphocytes. Biorxiv : the Preprint Server For Biology
Truex NL, Rondon A, Rössler SL, et al. (2023) Enhanced Vaccine Immunogenicity Enabled by Targeted Cytosolic Delivery of Tumor Antigens into Dendritic Cells. Acs Central Science. 9: 1835-1845
Yousefpour P, Ni K, Irvine DJ. (2023) Targeted modulation of immune cells and tissues using engineered biomaterials. Nature Reviews Bioengineering. 1: 107-124
Truex NL, Mohapatra S, Melo M, et al. (2023) Design of Cytotoxic T Cell Epitopes by Machine Learning of Human Degrons. Biorxiv : the Preprint Server For Biology
Nguyen KB, Roerden M, Copeland CJ, et al. (2023) Decoupled neoantigen cross-presentation by dendritic cells limits anti-tumor immunity against tumors with heterogeneous neoantigen expression. Elife. 12
Mota I, Patrucco E, Mastini C, et al. (2023) ALK peptide vaccination restores the immunogenicity of ALK-rearranged non-small cell lung cancer. Nature Cancer
Ma L, Hostetler A, Morgan DM, et al. (2023) Vaccine-boosted CAR T crosstalk with host immunity to reject tumors with antigen heterogeneity. Cell
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