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Tyler R. Simpson, Ph.D.

Affiliations: 
2013 Weill Cornell Medical College, New York, NY, United States 
Area:
Immunology, Oncology, Cell Biology
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James Patrick Allison grad student 2013 Weill Cornell Medical College
 (Defining the impact of CTLA-4 blockade immunotherapy and the tumor microenvironment on the anti-tumor activity of the CD4+ T cell compartment.)

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Publications

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Hanson A, Elpek K, Duong E, et al. (2020) ICOS agonism by JTX-2011 (vopratelimab) requires initial T cell priming and Fc cross-linking for optimal T cell activation and anti-tumor immunity in preclinical models. Plos One. 15: e0239595
Elpek K, Harvey C, Duong E, et al. (2016) Abstract A059: Efficacy of anti-ICOS agonist monoclonal antibodies in preclinical tumor models provides a rationale for clinical development as cancer immunotherapeutics Cancer Immunology Research. 4
LeBleu VS, Özdemir BC, Pentcheva-Hoang T, et al. (2016) Abstract IA15: Functional diversity of the pancreas tumor stroma Cancer Research. 76
Özdemir BC, Pentcheva-Hoang T, Carstens JL, et al. (2015) Depletion of Carcinoma-Associated Fibroblasts and Fibrosis Induces Immunosuppression and Accelerates Pancreas Cancer with Reduced Survival. Cancer Cell. 28: 831-833
Pentcheva-Hoang T, Simpson TR, Montalvo-Ortiz W, et al. (2014) Cytotoxic T lymphocyte antigen-4 blockade enhances antitumor immunity by stimulating melanoma-specific T-cell motility. Cancer Immunology Research. 2: 970-80
Özdemir BC, Pentcheva-Hoang T, Carstens JL, et al. (2014) Depletion of carcinoma-associated fibroblasts and fibrosis induces immunosuppression and accelerates pancreas cancer with reduced survival. Cancer Cell. 25: 719-34
Simpson TR, Li F, Montalvo-Ortiz W, et al. (2013) Fc-dependent depletion of tumor-infiltrating regulatory T cells co-defines the efficacy of anti-CTLA-4 therapy against melanoma. The Journal of Experimental Medicine. 210: 1695-710
Quezada SA, Peggs KS, Simpson TR, et al. (2011) Shifting the equilibrium in cancer immunoediting: from tumor tolerance to eradication. Immunological Reviews. 241: 104-18
Quezada SA, Simpson TR, Peggs KS, et al. (2010) Tumor-reactive CD4(+) T cells develop cytotoxic activity and eradicate large established melanoma after transfer into lymphopenic hosts. The Journal of Experimental Medicine. 207: 637-50
Simpson TR, Quezada SA, Allison JP. (2010) Regulation of CD4 T cell activation and effector function by inducible costimulator (ICOS). Current Opinion in Immunology. 22: 326-32
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