Tao Tan, Ph.D.
|2008-2013||Institute of Biomedical Engineering||Tianjin Medical University|
|2013-2016||Children’s Hospital of Chongqing Medical University||Chongqing Medical University|
|2016-||Biophysics and Physiology||State University of New York, Buffalo, Buffalo, NY, United States|
Area:Autism; Stress; Alzheimer's Diseases; Electrophysiology; Ion channel; rTMS
Google:"Tao Tan, university at buffalo"
My research mainly focuses on exploring the synaptic mechanisms of neural developmental diseases (autism, schizophrenia, stress) and degenerative diseases (Alzheimer’s Diseases), and trying novel none-invasive neuronal modulation strategies (repetitive transcranial magnetic stimulation, rTMS) on treating these diseases. Specifically, I investigate the synaptic action of various neuromodulators that are linked to mental illnesses, including disease susceptibility genes and stress. The major techniques include whole-cell patch-clamp recordings of ion channel and synaptic currents, multi-channel in vivo single-unit recording on free-moving mouse, viral-based in vivo gene transfer, biochemical and immunocytochemical detection of synaptic proteins, chemo-genetics manipulation of neuronal circuits, and behavioral assays.
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|Rein B, Tan T, Yang F, et al. (2020) Reversal of synaptic and behavioral deficits in a 16p11.2 duplication mouse model via restoration of the GABA synapse regulator Npas4. Molecular Psychiatry|
|Ai L, Tan T, Tang Y, et al. (2019) Endogenous formaldehyde is a memory-related molecule in mice and humans. Communications Biology. 2: 446|
|Rapanelli M, Tan T, Wang W, et al. (2019) Behavioral, circuitry, and molecular aberrations by region-specific deficiency of the high-risk autism gene Cul3. Molecular Psychiatry|
|Tan T, Chen J, Hu Y, et al. (2019) Dihydrotanshinone I inhibits the growth of osteosarcoma through the Wnt/β-catenin signaling pathway. Oncotargets and Therapy. 12: 5111-5122|
|Tan T, Wang W, Williams J, et al. (2018) Stress Exposure in Dopamine D4 Receptor Knockout Mice Induces Schizophrenia-Like Behaviors via Disruption of GABAergic Transmission. Schizophrenia Bulletin|
|Guo D, Gan J, Tan T, et al. (2018) Neonatal exposure of ketamine inhibited the induction of hippocampal long-term potentiation without impairing the spatial memory of adult rats. Cognitive Neurodynamics. 12: 377-383|
|Wang W, Rein B, Zhang F, et al. (2018) Chemogenetic Activation of Prefrontal Cortex Rescues Synaptic and Behavioral Deficits in a Mouse Model of 16p11.2 Deletion Syndrome. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience|
|Tan T, Wang W, Xu H, et al. (2018) Low-Frequency rTMS Ameliorates Autistic-Like Behaviors in Rats Induced by Neonatal Isolation Through Regulating the Synaptic GABA Transmission. Frontiers in Cellular Neuroscience. 12: 46|
|Tan T, Zhang Y, Luo W, et al. (2018) Formaldehyde induces diabetes-associated cognitive impairments. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. fj201701239R|
|Zhu B, Zhao L, Luo D, et al. (2018) Furin promotes dendritic morphogenesis and learning and memory in transgenic mice. Cellular and Molecular Life Sciences : Cmls|