Tao Tan, Ph.D.

2008-2013 Institute of Biomedical Engineering Tianjin Medical University 
 2013-2016 Children’s Hospital of Chongqing Medical University Chongqing Medical University 
 2016- Biophysics and Physiology State University of New York, Buffalo, Buffalo, NY, United States 
Autism; Stress; Alzheimer's Diseases; Electrophysiology; Ion channel; rTMS
"Tao Tan, university at buffalo"

My research mainly focuses on exploring the synaptic mechanisms of neural developmental diseases (autism, schizophrenia, stress) and degenerative diseases (Alzheimer’s Diseases), and trying novel none-invasive neuronal modulation strategies (repetitive transcranial magnetic stimulation, rTMS) on treating these diseases. Specifically, I investigate the synaptic action of various neuromodulators that are linked to mental illnesses, including disease susceptibility genes and stress. The major techniques include whole-cell patch-clamp recordings of ion channel and synaptic currents, multi-channel in vivo single-unit recording on free-moving mouse, viral-based in vivo gene transfer, biochemical and immunocytochemical detection of synaptic proteins, chemo-genetics manipulation of neuronal circuits, and behavioral assays.

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Xin Tian grad student 2008-2013 Tianjin Medical University, China
Zhen Yan post-doc 2016- SUNY Buffalo
Yu Tian Wang post-doc 2013-2016 UBC


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Zhiqian Tong collaborator 2010- Capital Medical University
Wei Wang collaborator 2013- SUNY Buffalo
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Rein B, Tan T, Yang F, et al. (2020) Reversal of synaptic and behavioral deficits in a 16p11.2 duplication mouse model via restoration of the GABA synapse regulator Npas4. Molecular Psychiatry
Ai L, Tan T, Tang Y, et al. (2019) Endogenous formaldehyde is a memory-related molecule in mice and humans. Communications Biology. 2: 446
Rapanelli M, Tan T, Wang W, et al. (2019) Behavioral, circuitry, and molecular aberrations by region-specific deficiency of the high-risk autism gene Cul3. Molecular Psychiatry
Tan T, Chen J, Hu Y, et al. (2019) Dihydrotanshinone I inhibits the growth of osteosarcoma through the Wnt/β-catenin signaling pathway. Oncotargets and Therapy. 12: 5111-5122
Tan T, Wang W, Williams J, et al. (2018) Stress Exposure in Dopamine D4 Receptor Knockout Mice Induces Schizophrenia-Like Behaviors via Disruption of GABAergic Transmission. Schizophrenia Bulletin
Guo D, Gan J, Tan T, et al. (2018) Neonatal exposure of ketamine inhibited the induction of hippocampal long-term potentiation without impairing the spatial memory of adult rats. Cognitive Neurodynamics. 12: 377-383
Wang W, Rein B, Zhang F, et al. (2018) Chemogenetic Activation of Prefrontal Cortex Rescues Synaptic and Behavioral Deficits in a Mouse Model of 16p11.2 Deletion Syndrome. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience
Tan T, Wang W, Xu H, et al. (2018) Low-Frequency rTMS Ameliorates Autistic-Like Behaviors in Rats Induced by Neonatal Isolation Through Regulating the Synaptic GABA Transmission. Frontiers in Cellular Neuroscience. 12: 46
Tan T, Zhang Y, Luo W, et al. (2018) Formaldehyde induces diabetes-associated cognitive impairments. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. fj201701239R
Zhu B, Zhao L, Luo D, et al. (2018) Furin promotes dendritic morphogenesis and learning and memory in transgenic mice. Cellular and Molecular Life Sciences : Cmls
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