R Benjamin Free

2003- National Institutes of Health, Bethesda, MD 
"R Free"
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David R. Sibley research scientist 2003- NIH
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Moritz AE, Bonifazi A, Guerrero AM, et al. (2020) Evidence for a stereoselective mechanism for bitopic activity by extended-length antagonists of the D3 dopamine receptor. Acs Chemical Neuroscience
Ågren R, Zeberg H, Maciej Stępniewski T, et al. (2020) A ligand with two modes of interaction with the dopamine D2 receptor - An induced-fit mechanism of insurmountable antagonism. Acs Chemical Neuroscience
Moritz AE, Free RB, Weiner WS, et al. (2020) Discovery, Optimization and Characterization of ML417: A Novel and Highly Selective D3 Dopamine Receptor Agonist. Journal of Medicinal Chemistry
Sanchez-Soto M, Verma RK, Willette BKA, et al. (2020) A structural basis for how ligand binding site changes can allosterically regulate GPCR signaling and engender functional selectivity. Science Signaling. 13
Keck TM, Free RB, Day MM, et al. (2019) Dopamine D4 Receptor-Selective Compounds Reveal Structure-Activity Relationships that Engender Agonist Efficacy. Journal of Medicinal Chemistry
Farino ZJ, Morgenstern TJ, Maffei A, et al. (2019) New roles for dopamine D and D receptors in pancreatic beta cell insulin secretion. Molecular Psychiatry
Chun LS, Vekariya RH, Free RB, et al. (2018) Structure-Activity Investigation of a G Protein-Biased Agonist Reveals Molecular Determinants for Biased Signaling of the DDopamine Receptor. Frontiers in Synaptic Neuroscience. 10: 2
Verma RK, Abramyan AM, Michino M, et al. (2018) The E2.65A mutation disrupts dynamic binding poses of SB269652 at the dopamine D2 and D3 receptors. Plos Computational Biology. 14: e1005948
Moritz AE, Benjamin Free R, Sibley DR. (2017) Advances and challenges in the search for D2 and D3 dopamine receptor-selective compounds. Cellular Signalling
Kumar V, Moritz AE, Keck TM, et al. (2017) Synthesis and Pharmacological Characterization of Novel trans-Cyclopropylmethyl-Linked Bivalent Ligands That Exhibit Selectivity and Allosteric Pharmacology at the Dopamine D3 Receptor (D3R). Journal of Medicinal Chemistry
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