Bruno M.D.C. Godinho

University Of Massachusetts Med Sch Worcester 
RNA Therapeutics, siRNA, Oligonucleotide Delivery, CNS
"Bruno Godinho"
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Hariharan VN, Caiazzi J, Miller R, et al. (2023) Extended Nucleic Acid (exNA): A Novel, Biologically Compatible Backbone that Significantly Enhances Oligonucleotide Efficacy in vivo. Research Square
Ferguson CM, Godinho BM, Alterman JF, et al. (2021) Comparative route of administration studies using therapeutic siRNAs show widespread gene modulation in Dorset sheep. Jci Insight. 6
Nikan M, Osborn MF, Coles AH, et al. (2017) Synthesis and Evaluation of Parenchymal Retention and Efficacy of a Metabolically Stable, O-phosphocholine-N-docosahexaenoyl-L-serine siRNA Conjugate in Mouse Brain. Bioconjugate Chemistry
Didiot MC, Hall LM, Coles AH, et al. (2016) Exosome-mediated Delivery of Hydrophobically Modified siRNA for Huntingtin mRNA Silencing. Molecular Therapy : the Journal of the American Society of Gene Therapy
Nikan M, Osborn MF, Coles AH, et al. (2016) Docosahexaenoic Acid Conjugation Enhances Distribution and Safety of siRNA upon Local Administration in Mouse Brain. Molecular Therapy. Nucleic Acids. 5: e344
Coles AH, Osborn MF, Alterman JF, et al. (2015) A High-Throughput Method for Direct Detection of Therapeutic Oligonucleotide-Induced Gene Silencing In Vivo. Nucleic Acid Therapeutics
Malhotra M, Toulouse A, Godinho BM, et al. (2015) RNAi therapeutics for brain cancer: current advancements in RNAi delivery strategies. Molecular Biosystems
Gooding M, Malhotra M, McCarthy DJ, et al. (2015) Synthesis and characterization of rabies virus glycoprotein-tagged amphiphilic cyclodextrins for siRNA delivery in human glioblastoma cells: in vitro analysis. European Journal of Pharmaceutical Sciences : Official Journal of the European Federation For Pharmaceutical Sciences. 71: 80-92
Godinho BM, Malhotra M, O'Driscoll CM, et al. (2015) Delivering a disease-modifying treatment for Huntington's disease. Drug Discovery Today. 20: 50-64
Godinho BM, Ogier JR, Quinlan A, et al. (2014) PEGylated cyclodextrins as novel siRNA nanosystems: correlations between polyethylene glycol length and nanoparticle stability. International Journal of Pharmaceutics. 473: 105-12
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