Brianna N. Smith

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2018- Cancer Biology Vanderbilt University, Nashville, TN 
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Publications

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Meyer CT, Smith BN, Wang J, et al. (2024) Expanded profiling of WD repeat domain 5 inhibitors reveals actionable strategies for the treatment of hematologic malignancies. Proceedings of the National Academy of Sciences of the United States of America. 121: e2408889121
Howard GC, Wang J, Rose KL, et al. (2024) Ribosome subunit attrition and activation of the p53-MDM4 axis dominate the response of MLL-rearranged cancer cells to WDR5 WIN site inhibition. Elife. 12
Monteith AJ, Ramsey HE, Silver AJ, et al. (2024) Lactate utilization enables metabolic escape to confer resistance to BET inhibition in acute myeloid leukemia. Cancer Research
Ramsey HE, Gorska AE, Smith BN, et al. (2023) TLR3 agonism augments CD47 inhibition in acute myeloid leukemia. Haematologica
Howard GC, Wang J, Rose KL, et al. (2023) Ribosome subunit attrition and activation of the p53-MDM4 axis dominate the response of MLL-rearranged cancer cells to WDR5 WIN site inhibition. Biorxiv : the Preprint Server For Biology
Fischer MA, Song Y, Arrate MP, et al. (2022) Selective inhibition of MCL1 overcomes venetoclax-resistance in a murine model of myelodysplastic syndromes. Haematologica
Cojocari D, Smith BN, Purkal JJ, et al. (2021) Pevonedistat and azacitidine upregulate NOXA () to increase sensitivity to venetoclax in preclinical models of acute myeloid leukemia. Haematologica
Villaume MT, Arrate MP, Ramsey HE, et al. (2021) The delta isoform of PI3K predominates in chronic myelomonocytic leukemia and can be targeted effectively with umbralisib and ruxolitinib. Experimental Hematology
Smith BN, Savona M, Komrokji RS. (2019) Challenges in Myelodysplastic/Myeloproliferative Neoplasms (MDS/MPN). Clinical Lymphoma, Myeloma & Leukemia. 19: 1-8
Hilton CB, Meggendorfer M, Sekeres MA, et al. (2019) Geno-Clinical Model for the Diagnosis of Bone Marrow Myeloid Neoplasms Blood. 134: 4238-4238
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