Mary Druse-Manteuffel, Ph.D.

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Dr. Druse-Manteuffel's laboratory has been interested in understanding the causes of the CNS damage that accompanies maternal alcohol consumption and exploring the possibility that some of the damage might be prevented by a therapeutic treatment. The major research emphasis of this laboratory has been the elucidation of the mechanism(s) by which ethanol impairs the development of the serotonin (5-HT) system and causes apoptosis to 5-HT neurons. Recent research focuses on the deleterious effects of ethanol on pro-survival and anti-apoptotic pathways. Additional studies examine cellular signaling pathways that mediate the neuroprotective effects of a 5-HT-1A agonist and of specific antioxidants. These in vivo and in vitro investigations use a combination of techniques, including cell culture, immunohistochemistry, western blots and real-time RT-PCR .

Mean distance: 20.56 (cluster 28)