Thomas Kukar, Ph.D.
Affiliations: | School of Medicine | Emory University, Atlanta, GA |
Area:
NeurodegenerationWebsite:
http://www.pharm.emory.edu/tkukar/Google:
"Thomas Kukar"Mean distance: 18.86 (cluster 28) | S | N | B | C | P |
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Publications
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| McEachin ZT, Gendron TF, Raj N, et al. (2020) Chimeric Peptide Species Contribute to Divergent Dipeptide Repeat Pathology in c9ALS/FTD and SCA36. Neuron |
| Chou CC, Zhang Y, Umoh ME, et al. (2018) TDP-43 pathology disrupts nuclear pore complexes and nucleocytoplasmic transport in ALS/FTD. Nature Neuroscience |
| Moore BD, Martin J, de Mena L, et al. (2017) Short Aβ peptides attenuate Aβ42 toxicity in vivo. The Journal of Experimental Medicine |
| Holler CJ, Taylor G, McEachin ZT, et al. (2016) Trehalose upregulates progranulin expression in human and mouse models of GRN haploinsufficiency: a novel therapeutic lead to treat frontotemporal dementia. Molecular Neurodegeneration. 11: 46 |
| Jung JI, Ran Y, Cruz PE, et al. (2014) Complex relationships between substrate sequence and sensitivity to alterations in γ-secretase processivity induced by γ-secretase modulators. Biochemistry. 53: 1947-57 |
| Jung JI, Ladd TB, Kukar T, et al. (2013) Steroids as γ-secretase modulators. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 27: 3775-85 |
| Verbeeck C, Deng Q, Dejesus-Hernandez M, et al. (2012) Expression of Fused in sarcoma mutations in mice recapitulates the neuropathology of FUS proteinopathies and provides insight into disease pathogenesis. Molecular Neurodegeneration. 7: 53 |
| Das P, Verbeeck C, Minter L, et al. (2012) Transient pharmacologic lowering of Aβ production prior to deposition results in sustained reduction of amyloid plaque pathology. Molecular Neurodegeneration. 7: 39 |
| Moore BD, Chakrabarty P, Levites Y, et al. (2012) Overlapping profiles of Aβ peptides in the Alzheimer's disease and pathological aging brains. Alzheimer's Research & Therapy. 4: 18 |
| Sagi SA, Lessard CB, Winden KD, et al. (2011) Substrate sequence influences γ-secretase modulator activity, role of the transmembrane domain of the amyloid precursor protein. The Journal of Biological Chemistry. 286: 39794-803 |