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Peter K. Stys, M.D., FRCP (C)

Affiliations: 
Departments of Clinical Neurosciences University of Calgary, Calgary, Alberta, Canada 
Area:
Axon physiology, Ca imaging, Ca stores, Confocal and 2-photon microsc, Electrophysiology, Glutamate Receptors, Myelin, Na channels, Neuroprotection, White matter injury
Website:
http://www.ucalgary.ca/styslab/Projects
Google:
"https://www.google.ca/search?q=voon+wee+yong&oq=voon+&aqs=chrome.1.69i57j0l5.3423j0j7&sourceid=chrome&espv=210&es_sm=119&ie=UTF-8#q=Peter%20stys"
Bio:

Understanding normal physiology and cellular/molecular injury mechanisms of axons, myelin and glial cells in the mammalian nervous system. These insights will drive the development for more effective therapies for common and debilitating disorders such as multiple sclerosis, spinal cord injury, brain trauma and stroke. The Stys lab utilizes diverse advanced laser-scanning microscopy methods, many of which are custom-designed and built, biochemical techniques and electrophysiology to investigate axon function and injury mechanisms.

Mean distance: 14.15 (cluster 11)
 		SNBCP
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Parents

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Bruce R. Ransom post-doc 1989-1992 Yale
Stephen G. Waxman post-doc 1989-1992 Yale

Children

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Shuxin Li grad student 2000 University of Ottawa
Jason R. Plemel post-doc 2013- University of Calgary
Andrew V. Caprariello post-doc 2014- University of Calgary
Abdeslam Mouihate research scientist Cumming School of Medicine University of Calgary

Collaborators

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Publications

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Teo W, Morgan ML, Stys PK. (2024) Quantitation of the physicochemical properties of myelin using Nile Red fluorescence spectroscopy. Journal of Neurochemistry
Tsutsui S, Morgan M, Tedford H, et al. (2022) Copper ions, prion protein and Aβ modulate Ca levels in central nervous system myelin in an NMDA receptor-dependent manner. Molecular Brain. 15: 67
't Hart BA, Luchicchi A, Schenk GJ, et al. (2021) Mechanistic underpinning of an inside-out concept for autoimmunity in multiple sclerosis. Annals of Clinical and Translational Neurology
Morgan ML, Brideau C, Teo W, et al. (2021) Label-free assessment of myelin status using birefringence microscopy. Journal of Neuroscience Methods. 109226
Teo W, Caprariello AV, Morgan ML, et al. (2021) Nile Red fluorescence spectroscopy reports early physicochemical changes in myelin with high sensitivity. Proceedings of the National Academy of Sciences of the United States of America. 118
Luchicchi A, Hart B', Frigerio I, et al. (2021) Axon-myelin unit blistering as early event in MS normal appearing white matter. Annals of Neurology
Chu TH, Cummins K, Stys PK. (2020) Traumatic Injury Reduces Amyloid Plaque Burden in the Transgenic 5xFAD Alzheimer's Mouse Spinal Cord. Journal of Alzheimer's Disease : Jad
Morgan ML, Kaushik DK, Stys PK, et al. (2020) Autofluorescence spectroscopy as a proxy for chronic white matter pathology. Multiple Sclerosis (Houndmills, Basingstoke, England). 1352458520948221
Plemel JR, Stratton JA, Michaels NJ, et al. (2020) Microglia response following acute demyelination is heterogeneous and limits infiltrating macrophage dispersion. Science Advances. 6: eaay6324
Grochmal J, Teo W, Gambhir H, et al. (2020) Spectral Characterization of Stem Cell-Derived Myelination within the Injured Adult PNS Using the Solvatochromic Dye Nile Red. Cells. 9
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